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Molecular Pharmacology

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OtherArticle

NEW SYNTHETIC CAFFEINE ANALOGS AS MODULATORS OF THE CHOLINERGIC SYSTEM

Camila Fabiani, Brunella Biscussi, Juan Pablo Munafo, Ana Paula Murray, Jeremias Corradi and Silvia Susana Antollini
Molecular Pharmacology December 30, 2021, MOLPHARM-AR-2021-000415; DOI: https://doi.org/10.1124/molpharm.121.000415
Camila Fabiani
1Instituto de Investigaciones Bioquímicas de Bahía Blanca, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur y Consejo Nacional de Investigaciones Científicas y Técnicas, Camino La Carrindanga km 7, Argentina
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Brunella Biscussi
2Instituto de Química del Sur, Departamento de Química, Universidad Nacional del Sur y Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Alem 1253, Argentina
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Juan Pablo Munafo
1Instituto de Investigaciones Bioquímicas de Bahía Blanca, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur y Consejo Nacional de Investigaciones Científicas y Técnicas, Camino La Carrindanga km 7, Argentina
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Ana Paula Murray
2Instituto de Química del Sur, Departamento de Química, Universidad Nacional del Sur y Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Alem 1253, Argentina
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  • For correspondence: silviant@criba.edu.ar
Jeremias Corradi
1Instituto de Investigaciones Bioquímicas de Bahía Blanca, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur y Consejo Nacional de Investigaciones Científicas y Técnicas, Camino La Carrindanga km 7, Argentina
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  • For correspondence: silviant@criba.edu.ar
Silvia Susana Antollini
1Instituto de Investigaciones Bioquímicas de Bahía Blanca, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur y Consejo Nacional de Investigaciones Científicas y Técnicas, Camino La Carrindanga km 7, Argentina
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  • For correspondence: silviant@criba.edu.ar
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  • Data Supplement

    • Supplemental Figures -

      Supplementary Figure S1.  Ligand-receptor interaction for the best binding conformation of each ligand in the
      human AChE structure (PDB code 4EY7). 

      Supplementary Figure S2.  Ligand-receptor interaction for the best binding conformation of each ligand in the
      mouse α1/δ interface of the nAChR (partially capped model).

      Supplementary Figure S3. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 2

      Supplementary Figure S4. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 3

      Supplementary Figure S5. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 4

      Supplementary Figure S6. HSQC and DEPT spectra in CDCl3 of 4

      Supplementary Figure S7. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 5

      Supplementary Figure S8. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 7

      Supplementary Figure S9. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 8

      Supplementary Figure S10. HSQC and DEPT spectra in CDCl3 of 8

      Supplementary Figure S11. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 9

      Supplementary Figure S12. HSQC and DEPT spectra in CDCl3 of 9

      Supplementary Figure S13. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 10

      Supplementary Figure S14. HSQC and DEPT spectra in CDCl3 of 10

      Supplementary Figure S15. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 11

      Supplementary Figure S16. DEPT spectra in CDCl3 of 11

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Molecular Pharmacology: 103 (2)
Molecular Pharmacology
Vol. 103, Issue 2
1 Feb 2023
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Caffeine analogs as modulators of the cholinergic system

Camila Fabiani, Brunella Biscussi, Juan Pablo Munafo, Ana Paula Murray, Jeremias Corradi and Silvia Susana Antollini
Molecular Pharmacology December 30, 2021, MOLPHARM-AR-2021-000415; DOI: https://doi.org/10.1124/molpharm.121.000415

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Caffeine analogs as modulators of the cholinergic system

Camila Fabiani, Brunella Biscussi, Juan Pablo Munafo, Ana Paula Murray, Jeremias Corradi and Silvia Susana Antollini
Molecular Pharmacology December 30, 2021, MOLPHARM-AR-2021-000415; DOI: https://doi.org/10.1124/molpharm.121.000415
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