Data Supplement

• Supplemental Figures -

  Supplementary Figure S1.  Ligand-receptor interaction for the best binding conformation of each ligand in the
  human AChE structure (PDB code 4EY7). 

  Supplementary Figure S2.  Ligand-receptor interaction for the best binding conformation of each ligand in the
  mouse α1/δ interface of the nAChR (partially capped model).

  Supplementary Figure S3. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 2

  Supplementary Figure S4. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 3

  Supplementary Figure S5. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 4

  Supplementary Figure S6. HSQC and DEPT spectra in CDCl3 of 4

  Supplementary Figure S7. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 5

  Supplementary Figure S8. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 7

  Supplementary Figure S9. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 8

  Supplementary Figure S10. HSQC and DEPT spectra in CDCl3 of 8

  Supplementary Figure S11. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 9

  Supplementary Figure S12. HSQC and DEPT spectra in CDCl3 of 9

  Supplementary Figure S13. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 10

  Supplementary Figure S14. HSQC and DEPT spectra in CDCl3 of 10

  Supplementary Figure S15. 1H NMR (300 MHz) and 13C NMR (75 MHz) spectra in CDCl3 of 11

  Supplementary Figure S16. DEPT spectra in CDCl3 of 11