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A Recombinant DDAH Based Biotherapeutics to Pharmacologically Lower ADMA, thus Improving Post Ischemic Cardiac Function and Cardiomyocyte Mitochondrial Activity

Young Lee, Jaipal Singh, Susan R Scott, Bradley Ellis, Pinar Zorlutuna and Meijing Wang
Molecular Pharmacology January 18, 2022, MOLPHARM-AR-2021-000394; DOI: https://doi.org/10.1124/molpharm.121.000394

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      Supplemental Figure 1. Effect of rDDAH-1 on cardiac function in mouse hearts without I/R.

      Supplemental Figure 2. Effect of rDDAH-1 on mitochondrial respiration capacity in adult male mouse cardiomyocytes.

      Supplemental Figure 3. Effect of ADMA and rDDAH-1 on NADPH oxidase activity.
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Lowering of ADMA by Pharmacological DDAH-1 in Heart

Young Lee, Jaipal Singh, Susan R Scott, Bradley Ellis, Pinar Zorlutuna and Meijing Wang
Molecular Pharmacology January 18, 2022, MOLPHARM-AR-2021-000394; DOI: https://doi.org/10.1124/molpharm.121.000394
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