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Molecular Pharmacology

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Michaelis-Menten quantification of ligand signalling bias applied to the promiscuous Vasopressin V2 receptor

Franziska Marie Heydenreich, Bianca Plouffe, Aurelien Rizk, Dalibor Milic, Joris Zhou, Billy Breton, Christian Le Gouill, Asuka Inoue, Michel Bouvier and Dmitry Veprintsev
Molecular Pharmacology July 2, 2022, MOLPHARM-AR-2022-000497; DOI: https://doi.org/10.1124/molpharm.122.000497
Franziska Marie Heydenreich
1Structural Studies, MRC Laboratory of Molecular Biology, United Kingdom
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  • ORCID record for Franziska Marie Heydenreich
  • For correspondence: dmitry.veprintsev@nottingham.ac.uk
Bianca Plouffe
2Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, United Kingdom
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Aurelien Rizk
3InterAx Biotech AG, Switzerland
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Dalibor Milic
4Department of Structural and Computational Biology, University of Vienna, Austria
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Joris Zhou
5Institute for Research in Immunology and Cancer, University of Montreal, Canada
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Billy Breton
5Institute for Research in Immunology and Cancer, University of Montreal, Canada
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Christian Le Gouill
6University of Montreal, Canada
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Asuka Inoue
7Tohoku University, Japan
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Michel Bouvier
8Department of Biochemistry and Molec ular Medicine, University of Montreal, Canada
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  • ORCID record for Michel Bouvier
  • For correspondence: dmitry.veprintsev@nottingham.ac.uk
Dmitry Veprintsev
9School of Life Sciences, University of Nottingham, United Kingdom
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  • For correspondence: dmitry.veprintsev@nottingham.ac.uk
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Article Information

MOLPHARM-AR-2022-000497
DOI 
https://doi.org/10.1124/molpharm.122.000497
PubMed 
35779859

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Published online July 2, 2022.

Article Versions

  • You are currently viewing an Earlier version of this article (July 2, 2022 - 02:31).
  • View the most recent version of this article
Copyright & Usage 
Copyright © 2020 American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Franziska Marie Heydenreich1,*,
  2. Bianca Plouffe2,
  3. Aurelien Rizk3,
  4. Dalibor Milic4,
  5. Joris Zhou5,
  6. Billy Breton5,
  7. Christian Le Gouill6,
  8. Asuka Inoue7,
  9. Michel Bouvier8,*, and
  10. Dmitry Veprintsev9,*
  1. 1Structural Studies, MRC Laboratory of Molecular Biology, United Kingdom
  2. 2Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, United Kingdom
  3. 3InterAx Biotech AG, Switzerland
  4. 4Department of Structural and Computational Biology, University of Vienna, Austria
  5. 5Institute for Research in Immunology and Cancer, University of Montreal, Canada
  6. 6University of Montreal, Canada
  7. 7Tohoku University, Japan
  8. 8Department of Biochemistry and Molec ular Medicine, University of Montreal, Canada
  9. 9School of Life Sciences, University of Nottingham, United Kingdom
  1. ↵* Corresponding Author:
    Dmitry Veprintsev, School of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, N/A, United Kingdom. E-mail: dmitry.veprintsev{at}nottingham.ac.uk
  2. * Corresponding Author; email: michel.bouvier{at}umontreal.ca
  3. * Corresponding Author; email: dmitry.veprintsev{at}nottingham.ac.uk

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Molecular Pharmacology: 102 (3)
Molecular Pharmacology
Vol. 102, Issue 3
1 Sep 2022
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OtherArticle

Michaelis Menten quantification of GPCR-G protein signalling

Franziska Marie Heydenreich, Bianca Plouffe, Aurelien Rizk, Dalibor Milic, Joris Zhou, Billy Breton, Christian Le Gouill, Asuka Inoue, Michel Bouvier and Dmitry Veprintsev
Molecular Pharmacology July 2, 2022, MOLPHARM-AR-2022-000497; DOI: https://doi.org/10.1124/molpharm.122.000497

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OtherArticle

Michaelis Menten quantification of GPCR-G protein signalling

Franziska Marie Heydenreich, Bianca Plouffe, Aurelien Rizk, Dalibor Milic, Joris Zhou, Billy Breton, Christian Le Gouill, Asuka Inoue, Michel Bouvier and Dmitry Veprintsev
Molecular Pharmacology July 2, 2022, MOLPHARM-AR-2022-000497; DOI: https://doi.org/10.1124/molpharm.122.000497
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