Optimized pyridazinone nutrient channel inhibitors are potent and specific antimalarial leads

Michelle M Butler; Samanthi L. Waidyarachchi; Jinfeng Shao; Son T. Nguyen; Xiaoyuan Ding; Steven C. Cardinale; Lucas R. Morin; Steven M. Kwasny; Mai Ito; Jeanine Gezelle; Maria B. Jiminez-Di­az; Inigo Angulo-Barturen; Robert T. Jacobs; Jeremy N. Burrows; Zachary D. Aron; Terry L. Bowlin; Sanjay A. Desai

doi:10.1124/molpharm.122.000549

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Optimized pyridazinone nutrient channel inhibitors are potent and specific antimalarial leads

Michelle M Butler, Samanthi L. Waidyarachchi, Jinfeng Shao, Son T. Nguyen, Xiaoyuan Ding, Steven C. Cardinale, Lucas R. Morin, Steven M. Kwasny, Mai Ito, Jeanine Gezelle, Maria B. Jiminez-Diaz, Inigo Angulo-Barturen, Robert T. Jacobs, Jeremy N. Burrows, Zachary D. Aron, Terry L. Bowlin and Sanjay A. Desai

Molecular Pharmacology July 7, 2022, MOLPHARM-AR-2022-000549; DOI: https://doi.org/10.1124/molpharm.122.000549

Michelle M Butler

1Microbiotix, Inc., United States

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For correspondence: mbutler@microbiotix.com

Samanthi L. Waidyarachchi

1Microbiotix, Inc., United States

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Jinfeng Shao

2Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States

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Son T. Nguyen

1Microbiotix, Inc., United States

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Xiaoyuan Ding

1Microbiotix, Inc., United States

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Steven C. Cardinale

1Microbiotix, Inc., United States

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Lucas R. Morin

1Microbiotix, Inc., United States

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Steven M. Kwasny

1Microbiotix, Inc., United States

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Mai Ito

2Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States

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Jeanine Gezelle

2Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States

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Maria B. Jiminez-Diaz

3The Art of Discovery SL, Spain

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Inigo Angulo-Barturen

3The Art of Discovery SL, Spain

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Robert T. Jacobs

4Medicines for Malaria Venture, Switzerland

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Jeremy N. Burrows

4Medicines for Malaria Venture, Switzerland

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Zachary D. Aron

1Microbiotix, Inc., United States

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Terry L. Bowlin

1Microbiotix, Inc., United States

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Sanjay A. Desai

5LMVR/NIAID, National Institutes of Health, United States

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Molecular Pharmacology

Vol. 102, Issue 3

1 Sep 2022

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