Data Supplement

• Supplemental Data -

  Supplemental Scheme 1: Synthesis of pyridazinone compounds. Reagents and conditions: (a) N₂H₄.H₂O, EtOH, reflux, 7 h, 61 %. (b) 3-Nitrobenzenesulfonate, NaOH, H₂O, 100 °C, 2 h (c) HSO₃Cl, PCl₅, CHCl₃, 0 °C to RT, 5h, 33.8 %. (d) DIPEA, DMF, 3 h, RT, 70%.

  Supplemental Table 1. In vitro Safety Panel and CYP profiling results for MBX-4055.

  Supplemental Table 2. Pharmacokinetic parameters for compounds MBX-2366, MBX-3318, MBX-3477A and 3976.

  Supplemental Table 3. Murine tolerability for compounds MBX-2366, 3318, 3477A, 3976 and 4055.
  

  Supplemental Figure 1. Murine pharmacokinetics