Data Supplement

• Supplemental Data -

  Supplemental Table S1. Competitive binding study result of cold upacicalcet, L-tryptophan and cinacalcet using
  a scintillation proximity assay.

  Supplemental Fig. S1. Detection of CaSR expression in HEK-CaSR whole cell protein by anti-CaSR antibody in western blot analysis.

  Supplemental Fig. S2. Effect of the mutation of CaSR protein on IP-1 accumulation of transiently CaSR expressing HEK-293T cells.

  Supplemental Fig. S3. Estimation of upacicalcet binding mode based on molecular dynamics simulation (simulations 2 and 3).