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Molecular Pharmacology

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The isoleucine at position 118 in transmembrane 2 is responsible for the selectivity of xamoterol, nebivolol and ICI89406 for the human β1-adrenoceptor.

Victor Jun Yu Lim, Richard George William Proudman, Stefania Monteleone, Peter Kolb and Jillian Glenda Baker
Molecular Pharmacology November 9, 2022, MOLPHARM-AR-2022-000583; DOI: https://doi.org/10.1124/molpharm.122.000583
Victor Jun Yu Lim
1Institute of Pharmaceutical Chemistry, Philipps-University Marburg, United Kingdom
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Richard George William Proudman
2University of Nottingham, Cell Signalling, United Kingdom
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Stefania Monteleone
3Institute of Pharmaceutical Chemistry, Philipps-University Marburg, Germany
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Peter Kolb
4Pharmaceutical Chemistry, Philipps-University Marburg, Germany
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Jillian Glenda Baker
5Cell Signalling, University of Nottingham, United Kingdom
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  • ORCID record for Jillian Glenda Baker
  • For correspondence: jillian.baker@nottingham.ac.uk
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Article Information

MOLPHARM-AR-2022-000583
DOI 
https://doi.org/10.1124/molpharm.122.000583
PubMed 
36351797

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Published online November 9, 2022.

Article Versions

  • You are currently viewing an Earlier version of this article (November 9, 2022 - 13:21).
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Copyright & Usage 
Copyright © 2020 American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Victor Jun Yu Lim1,
  2. Richard George William Proudman2,
  3. Stefania Monteleone3,
  4. Peter Kolb4, and
  5. Jillian Glenda Baker5,*
  1. 1Institute of Pharmaceutical Chemistry, Philipps-University Marburg, United Kingdom
  2. 2University of Nottingham, Cell Signalling, United Kingdom
  3. 3Institute of Pharmaceutical Chemistry, Philipps-University Marburg, Germany
  4. 4Pharmaceutical Chemistry, Philipps-University Marburg, Germany
  5. 5Cell Signalling, University of Nottingham, United Kingdom
  1. ↵* Corresponding Author:
    Jillian Glenda Baker, Cell Signalling, University of Nottingham, C floor Medical School, Queens Medical Centre, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, United Kingdom. E-mail: jillian.baker{at}nottingham.ac.uk

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Article usage: November 2022 to January 2023

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Dec 2022351029
Jan 20233026260

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Molecular Pharmacology: 103 (2)
Molecular Pharmacology
Vol. 103, Issue 2
1 Feb 2023
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The isoleucine at position 118 in transmembrane 2 is responsible for the selectivity of xamoterol, nebivolol and ICI89406 for the human β1-adrenoceptor.
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β1-selectivity of xamoterol and nebivolol

Victor Jun Yu Lim, Richard George William Proudman, Stefania Monteleone, Peter Kolb and Jillian Glenda Baker
Molecular Pharmacology November 9, 2022, MOLPHARM-AR-2022-000583; DOI: https://doi.org/10.1124/molpharm.122.000583

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OtherArticle

β1-selectivity of xamoterol and nebivolol

Victor Jun Yu Lim, Richard George William Proudman, Stefania Monteleone, Peter Kolb and Jillian Glenda Baker
Molecular Pharmacology November 9, 2022, MOLPHARM-AR-2022-000583; DOI: https://doi.org/10.1124/molpharm.122.000583
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