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The isoleucine at position 118 in transmembrane 2 is responsible for the selectivity of xamoterol, nebivolol and ICI89406 for the human β1-adrenoceptor.
Victor Jun Yu Lim, Richard George William Proudman, Stefania Monteleone, Peter Kolb and Jillian Glenda Baker
Molecular Pharmacology November 9, 2022, MOLPHARM-AR-2022-000583; DOI: https://doi.org/10.1124/molpharm.122.000583
Victor Jun Yu Lim
1Institute of Pharmaceutical Chemistry, Philipps-University Marburg, United Kingdom
Richard George William Proudman
2University of Nottingham, Cell Signalling, United Kingdom
Stefania Monteleone
3Institute of Pharmaceutical Chemistry, Philipps-University Marburg, Germany
Peter Kolb
4Pharmaceutical Chemistry, Philipps-University Marburg, Germany
Jillian Glenda Baker
5Cell Signalling, University of Nottingham, United Kingdom
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β1-selectivity of xamoterol and nebivolol
Victor Jun Yu Lim, Richard George William Proudman, Stefania Monteleone, Peter Kolb and Jillian Glenda Baker
Molecular Pharmacology November 9, 2022, MOLPHARM-AR-2022-000583; DOI: https://doi.org/10.1124/molpharm.122.000583
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