Mutual Cooperativity of Three Allosteric Sites on the Dopamine D1 Receptor

Xushan Wang; Erik J Hembre; Paul J Goldsmith; James P Beck; Kjell A Svensson; Francis S. Willard; Robert F Bruns

doi:10.1124/molpharm.122.000605

Article Information

MOLPHARM-AR-2022-000605

DOI

https://doi.org/10.1124/molpharm.122.000605

Published By

American Society for Pharmacology and Experimental Therapeutics

Print ISSN

0026-895X

Online ISSN

1521-0111

History

Published online December 12, 2022.

© 2020 The Authors. This is an open access article under the terms of the Creative Commons Attribution CC BY License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

Author Information

Xushan Wang1,
Erik J Hembre2,
Paul J Goldsmith3,
James P Beck4,
Kjell A Svensson5,
Francis S. Willard1,*, and
Robert F Bruns6

¹Molecular Pharmacology, Lilly Research Laboratories, United States
²DCRT, Eli Lilly and Company, United States
³Lilly Research Center, Lilly Research Laboratories, United Kingdom
⁴Discovery Chemistry Research and Technologies, Lilly Research Laboratories, United States
⁵Neuroscience, Eli Lilly and Company, United States
⁶retired, United States

↵* Corresponding Author:
Francis S. Willard, Molecular Pharmacology, Lilly Research Laboratories, Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, 46285, United States. E-mail: willardfs{at}lilly.com