CRISPR/Cas9-mediated induction of relapse-specific NT5C2 and PRPS1 mutations confers thiopurine resistance as a relapsed lymphoid leukemia model

Thao Thu Thi Nguyen; Yoichi Tanaka; Masashi Sanada; Masumi Hosaka; Minori Tamai; Keiko Kagami; Chiaki Komatsu; Shinpei Somazu; Daisuke Harama; Shin Kasai; Atsushi Watanabe; Koushi Akahane; Kumiko Goi; Takeshi Inukai

doi:10.1124/molpharm.122.000546

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**CRISPR/Cas9-mediated induction of relapse-specific NT5C2 and PRPS1 mutations confers thiopurine resistance as a relapsed lymphoid leukemia model**

Thao Thu Thi Nguyen, Yoichi Tanaka, Masashi Sanada, Masumi Hosaka, Minori Tamai, Keiko Kagami, Chiaki Komatsu, Shinpei Somazu, Daisuke Harama, Shin Kasai, Atsushi Watanabe, Koushi Akahane, Kumiko Goi and Takeshi Inukai

Molecular Pharmacology January 20, 2023, MOLPHARM-AR-2022-000546; DOI: https://doi.org/10.1124/molpharm.122.000546

Thao Thu Thi Nguyen

1Pediatrics, University of Yamanashi, Japan

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Yoichi Tanaka

2Division of Medicinal Safety Science, National Institute of Health Sciences, Japan

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Masashi Sanada

3Advanced Diagnostic Research Department, Clinical Research Center, National Hospital Organization, Nagoya Medical Center, Japan

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Masumi Hosaka

4Advanced Diagnostic Research Department, Clinical Research Center, National Hospital Organization, National Hospital Organization, Nagoya Medical Center, Japan

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Minori Tamai

1Pediatrics, University of Yamanashi, Japan

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Keiko Kagami

1Pediatrics, University of Yamanashi, Japan

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Chiaki Komatsu

1Pediatrics, University of Yamanashi, Japan

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Shinpei Somazu

1Pediatrics, University of Yamanashi, Japan

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Daisuke Harama

1Pediatrics, University of Yamanashi, Japan

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Shin Kasai

1Pediatrics, University of Yamanashi, Japan

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Atsushi Watanabe

1Pediatrics, University of Yamanashi, Japan

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Koushi Akahane

1Pediatrics, University of Yamanashi, Japan

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Kumiko Goi

1Pediatrics, University of Yamanashi, Japan

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Takeshi Inukai

5University of Yamanashi, Japan

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For correspondence: tinukai@yamanashi.ac.jp

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Molecular Pharmacology

Vol. 103, Issue 2

1 Feb 2023

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