Data Supplement

• Supplemental Data -

  Table S1. Conditions of radioligand binding assays: adenosine receptors
  

  Table S2. Conditions of radioligand binding assays: adenosine transporter and other receptors/transporters/ion channels
  

  Table S3. Crystallographic statistics
  

  Table S4. Affinity of istradefylline for the various subtypes of adenosine receptors in different species
  

  Figure S1. Electron density of KW-6356 and istradefylline in co-crystal structures.
  

  Figure S2. The overall structure comparison of KW-6356 and istradefylline-bound A2A receptor.
  

  Figure S3. The comparison of the binding modes of istradefylline with caffeine.
  

  Figure S4. Superimposition of KW-6356 onto the ligand binding pocket of ZM241385.
  

  Figure S5. Superimposition of A2A receptor/KW-6356 on AT1 receptor/olmesartan.