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Molecular Pharmacology

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A Point Mutation at C151 of Keap1 of Mice Abrogates NRF2 Signaling, Cytoprotection In Vitro and Hepatoprotection In Vivo by Bardoxolone Methyl (CDDO-Me)

Tonibelle Gatbonton-Schwager, Yoko Yagishita, Tanvi Joshi, Nobunao Wakabayashi, Harini Srinivasan, Takafumi Suzuki, Masayuki Yamamoto and Thomas W Kensler
Molecular Pharmacology May 15, 2023, MOLPHARM-AR-2023-000671; DOI: https://doi.org/10.1124/molpharm.123.000671
Tonibelle Gatbonton-Schwager
1Translational Research Program, Fred Hutchinson Cancer Center, United States
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Yoko Yagishita
1Translational Research Program, Fred Hutchinson Cancer Center, United States
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Tanvi Joshi
1Translational Research Program, Fred Hutchinson Cancer Center, United States
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Nobunao Wakabayashi
1Translational Research Program, Fred Hutchinson Cancer Center, United States
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Harini Srinivasan
2Genomics and Bioinformatics Core, Fred Hutchinson Cancer Center, United States
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Takafumi Suzuki
3Tohoku University Graduate School of Medicine, Japan
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Masayuki Yamamoto
4Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Japan
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Thomas W Kensler
1Translational Research Program, Fred Hutchinson Cancer Center, United States
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  • For correspondence: tkensler@fredhutch.org
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Article Information

MOLPHARM-AR-2023-000671
DOI 
https://doi.org/10.1124/molpharm.123.000671
PubMed 
37188495

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0026-895X
Online ISSN 
1521-0111
History 
  • Published online May 15, 2023.

Copyright & Usage 
© 2023 The Authors. This is an open access article under the terms of the Creative Commons Attribution CC BY License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

Author Information

  1. Tonibelle Gatbonton-Schwager1,
  2. Yoko Yagishita1,
  3. Tanvi Joshi1,
  4. Nobunao Wakabayashi1,
  5. Harini Srinivasan2,
  6. Takafumi Suzuki3,
  7. Masayuki Yamamoto4, and
  8. Thomas W Kensler1,*
  1. 1Translational Research Program, Fred Hutchinson Cancer Center, United States
  2. 2Genomics and Bioinformatics Core, Fred Hutchinson Cancer Center, United States
  3. 3Tohoku University Graduate School of Medicine, Japan
  4. 4Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Japan
  1. ↵* Corresponding Author:
    Thomas W Kensler, Translational Research Program, Fred Hutchinson Cancer Center, M5A833, 1100 Fairview Ave N, Seattle, Washington, 98109, United States. E-mail: tkensler{at}fredhutch.org

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Molecular Pharmacology: 103 (6)
Molecular Pharmacology
Vol. 103, Issue 6
1 Jun 2023
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Cysteine151 in Keap1 Drives CDDO-Me Pharmacodynamic Action

Tonibelle Gatbonton-Schwager, Yoko Yagishita, Tanvi Joshi, Nobunao Wakabayashi, Harini Srinivasan, Takafumi Suzuki, Masayuki Yamamoto and Thomas W Kensler
Molecular Pharmacology May 15, 2023, MOLPHARM-AR-2023-000671; DOI: https://doi.org/10.1124/molpharm.123.000671

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Cysteine151 in Keap1 Drives CDDO-Me Pharmacodynamic Action

Tonibelle Gatbonton-Schwager, Yoko Yagishita, Tanvi Joshi, Nobunao Wakabayashi, Harini Srinivasan, Takafumi Suzuki, Masayuki Yamamoto and Thomas W Kensler
Molecular Pharmacology May 15, 2023, MOLPHARM-AR-2023-000671; DOI: https://doi.org/10.1124/molpharm.123.000671
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