A Point Mutation at C151 of Keap1 of Mice Abrogates NRF2 Signaling, Cytoprotection In Vitro and Hepatoprotection In Vivo by Bardoxolone Methyl (CDDO-Me)

Tonibelle Gatbonton-Schwager; Yoko Yagishita; Tanvi Joshi; Nobunao Wakabayashi; Harini Srinivasan; Takafumi Suzuki; Masayuki Yamamoto; Thomas W Kensler

doi:10.1124/molpharm.123.000671

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**A Point Mutation at C151 of Keap1 of Mice Abrogates NRF2 Signaling, Cytoprotection In Vitro and Hepatoprotection In Vivo by Bardoxolone Methyl (CDDO-Me)**

Tonibelle Gatbonton-Schwager, Yoko Yagishita, Tanvi Joshi, Nobunao Wakabayashi, Harini Srinivasan, Takafumi Suzuki, Masayuki Yamamoto and Thomas W Kensler

Molecular Pharmacology May 15, 2023, MOLPHARM-AR-2023-000671; DOI: https://doi.org/10.1124/molpharm.123.000671

Tonibelle Gatbonton-Schwager

1Translational Research Program, Fred Hutchinson Cancer Center, United States

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Yoko Yagishita

1Translational Research Program, Fred Hutchinson Cancer Center, United States

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Tanvi Joshi

1Translational Research Program, Fred Hutchinson Cancer Center, United States

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Nobunao Wakabayashi

1Translational Research Program, Fred Hutchinson Cancer Center, United States

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Harini Srinivasan

2Genomics and Bioinformatics Core, Fred Hutchinson Cancer Center, United States

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Takafumi Suzuki

3Tohoku University Graduate School of Medicine, Japan

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Masayuki Yamamoto

4Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Japan

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Thomas W Kensler

1Translational Research Program, Fred Hutchinson Cancer Center, United States

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ORCID record for Thomas W Kensler
For correspondence: tkensler@fredhutch.org

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Molecular Pharmacology

Vol. 103, Issue 6

1 Jun 2023

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Cysteine151 in Keap1 Drives CDDO-Me Pharmacodynamic Action

Tonibelle Gatbonton-Schwager, Yoko Yagishita, Tanvi Joshi, Nobunao Wakabayashi, Harini Srinivasan, Takafumi Suzuki, Masayuki Yamamoto and Thomas W Kensler

Molecular Pharmacology May 15, 2023, MOLPHARM-AR-2023-000671; DOI: https://doi.org/10.1124/molpharm.123.000671

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Cysteine151 in Keap1 Drives CDDO-Me Pharmacodynamic Action

Tonibelle Gatbonton-Schwager, Yoko Yagishita, Tanvi Joshi, Nobunao Wakabayashi, Harini Srinivasan, Takafumi Suzuki, Masayuki Yamamoto and Thomas W Kensler

Molecular Pharmacology May 15, 2023, MOLPHARM-AR-2023-000671; DOI: https://doi.org/10.1124/molpharm.123.000671

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**A Point Mutation at C151 of Keap1 of Mice Abrogates NRF2 Signaling, Cytoprotection In Vitro and Hepatoprotection In Vivo by Bardoxolone Methyl (CDDO-Me)**

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