Data Supplement

• Supplemental Data -

  Supplemental Data. Ordinary differential equations.

  Supplemental Table 1. Antibody affinity towards different amyloid species.

  Supplemental Table 2. Physiological parameters and parameters for non-linear amyloid aggregation cascade.

  Supplemental Table 3. Antibody molecular weight used to calculate dose.

  Supplemental Table 4. PK parameters used in model validation.

  Supplemental Table 5. PD endpoint used in model validation.

  Supplemental Table 6. Parameters used in the simulation of Drug A, B, C and D scenario.

  Supplemental Fig. 1. Observed vs. Predicted values for Gantenerumab PK and changes in the amyloid PET SUVR.
  

  Supplemental Fig. 2. Observed vs. Predicted values for Bapineuzumab PK and changes in the amyloid PET SUVR.

  Supplemental Fig. 3. Observed vs. Predicted values for Crenezumab PK and changes in the amyloid PET SUVR.

  Supplemental Fig. 4. Observed dose/weight-normalized solanezumab concentration vs. Predicted.