Data Supplement

• Supplemental Data -

  SUPPLEMENTARY TABLE 1. MTT test exhibiting antileukemic and anticancer activity of TP10 and fluoroquinolone conjugates.
  

  SUPPLEMENTARY TABLE 2. MTT test performed on Jurkat cells.
  

  SUPPLEMENTARY TABLE 3. Bacteriostatic selectivity of TP10 and selected conjugates.
  

  SUPPLEMENTARY TABLE 4. Malignancy selectivity of TP10 and its selected conjugates.
  

  SUPPLEMENTARY TABLE 5. Normalized to HC₅₀ Malignancy Selectivity Index.
  

  SUPPLEMENTARY TABLE 6. Improved anti-topoisomerase activities of TP10 conjugates.
  

  SUPPLEMENTARY FIGURE 1. Mitochondrial morphology and potential evaluation using fluorescence confocal microscopy (JC-1).
  

  SUPPLEMENTARY FIGURE 2. Confocal microscopy visualization of cell cytoskeleton.
  

  SUPPLEMENTARY FIGURE 3. MS spectra of the nuclear protein fractions.
  

  SUPPLEMENTARY FIGURE 4. MS spectra: the cytoplasmic protein fractions of HEK293 and HL60.
  

• Supplemental Movie 1 -

  SUPPLEMENTARY MOVIE 1. Water permeation.

• Supplemental Movie 2 -

  SUPPLEMENTARY MOVIE 2. Configurations of the dsDNA-ligand system.