Data Supplement

• Supplemental Figures -

  Suppl. Figure 1. Protein sequence alignment of human and zebrafish H₁ receptors.
  

  Suppl. Figure 2. Screening of histamine receptor ligands for binding to the human and zebrafish H₁ receptors.
  

  Suppl. Figure 3. Specific binding of [³H]-mepyramine on HEK-293T cell membranes.
  

  Suppl. figure 4. Competitive antagonism of H₁R antagonists on histamine-induced NFAT activation in human and zebrafish H₁ receptors.
  

  Suppl. figure 5. Exploratory CAVER analysis.