Ketamine and major ketamine metabolites function as allosteric modulators of opioid receptors

Ivone Gomes; Achla Gupta; Elyssa B. Margolis; Lloyd D. Fricker; Lakshmi A. Devi

doi:10.1124/molpharm.124.000947

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Ketamine and major ketamine metabolites function as allosteric modulators of opioid receptors

Ivone Gomes, Achla Gupta, Elyssa B. Margolis, Lloyd D. Fricker and Lakshmi A. Devi

Molecular Pharmacology August 26, 2024, MOLPHARM-AR-2024-000947; DOI: https://doi.org/10.1124/molpharm.124.000947

Ivone Gomes

1Department of Pharmacology & Systems Therapeutics, Mount Sinai School of Medicine, United States

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Achla Gupta

2Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, United States

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Elyssa B. Margolis

3Department of Neurology, University of California, San Francisco, United States

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Lloyd D. Fricker

4Department of Molecular Pharmacology, Albert Einstein College of Medicine, United States

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Lakshmi A. Devi

5Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, United States

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ORCID record for Lakshmi A. Devi
For correspondence: lakshmi.devi@mssm.edu

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Molecular Pharmacology

Vol. 106, Issue 4

1 Oct 2024

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Ketamine is an opioid receptor allosteric modulator

Ivone Gomes, Achla Gupta, Elyssa B. Margolis, Lloyd D. Fricker and Lakshmi A. Devi

Molecular Pharmacology August 26, 2024, MOLPHARM-AR-2024-000947; DOI: https://doi.org/10.1124/molpharm.124.000947

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Ketamine is an opioid receptor allosteric modulator

Ivone Gomes, Achla Gupta, Elyssa B. Margolis, Lloyd D. Fricker and Lakshmi A. Devi

Molecular Pharmacology August 26, 2024, MOLPHARM-AR-2024-000947; DOI: https://doi.org/10.1124/molpharm.124.000947

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