Probing the Chemical Space of Guanidino-Carboxylic Acids to Identify the First Blockers of the Creatine-Transporter-1

Clemens V Farr; Yi Xiao; Ali El-Kasaby; Manuel Schupp; Matej Hotka; Giovanni Di Mauro; Amy Clarke; Miryam Pastor Fernandez; Walter Sandtner; Thomas Stockner; Christoph Klade; Nuno Maulide; Michael Freissmuth

doi:10.1124/molpharm.124.000995

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Probing the Chemical Space of Guanidino-Carboxylic Acids to Identify the First Blockers of the Creatine-Transporter-1

Clemens V Farr, Yi Xiao, Ali El-Kasaby, Manuel Schupp, Matej Hotka, Giovanni Di Mauro, Amy Clarke, Miryam Pastor Fernandez, Walter Sandtner, Thomas Stockner, Christoph Klade, Nuno Maulide and Michael Freissmuth

Molecular Pharmacology September 25, 2024, MOLPHARM-AR-2024-000995; DOI: https://doi.org/10.1124/molpharm.124.000995

Clemens V Farr

1Institute of Pharmacology; Center of Physiology and Pharmacology, Medical University of Vienna, Austria

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Yi Xiao

2Institute of Organic Chemistry, University of Vienna, Austria

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Ali El-Kasaby

3Institute of Pharmacology, Medical University of Vienna, Austria

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Manuel Schupp

2Institute of Organic Chemistry, University of Vienna, Austria

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Matej Hotka

1Institute of Pharmacology; Center of Physiology and Pharmacology, Medical University of Vienna, Austria

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Giovanni Di Mauro

2Institute of Organic Chemistry, University of Vienna, Austria

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Amy Clarke

1Institute of Pharmacology; Center of Physiology and Pharmacology, Medical University of Vienna, Austria

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Miryam Pastor Fernandez

2Institute of Organic Chemistry, University of Vienna, Austria

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Walter Sandtner

4Medical University of Vienna, Austria

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Thomas Stockner

5Pharmacology, Medical University of Vienna, Austria

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Christoph Klade

6AOP Orphan Pharmaceuticals GmbH, Austria

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Nuno Maulide

2Institute of Organic Chemistry, University of Vienna, Austria

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Michael Freissmuth

7Institute of Pharmacology, Centre of Physiology and Pharmacology, Medical University of Vienna, Austria

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ORCID record for Michael Freissmuth
For correspondence: michael.freissmuth@meduniwien.ac.at

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Molecular Pharmacology

Vol. 106, Issue 4

1 Oct 2024

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Full and partial inhibitors of CRT-1

Molecular Pharmacology September 25, 2024, MOLPHARM-AR-2024-000995; DOI: https://doi.org/10.1124/molpharm.124.000995

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Full and partial inhibitors of CRT-1

Molecular Pharmacology September 25, 2024, MOLPHARM-AR-2024-000995; DOI: https://doi.org/10.1124/molpharm.124.000995

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