Data Supplement

• Supplemental Data -

  Supplementary Figure 1. Structures of compounds previously reported to inhibit CRT 1 or creatine uptake.
  

  Supplementary Table 1. Compilation of compounds, which were tested for inhibition of creatine uptake and inhibited uptake by ≥25%.
  

  Supplementary Table 2. Compilation of compounds, which were tested for inhibition of creatine uptake and failed to suppress uptake by ≥20%.
  

  Supplementary Figure 2. Mapping of ligand interaction sites.
  

  
  

• Supplemental PDB -

  ATPCA.
  

• Supplemental PDB -

  Compound1.
  

• Supplemental PDB -

  GiDi1254.
  

• Supplemental PDB -

  GiDi1257.
  

• Supplemental PDB -

  hCRT1_Homology_Model.
  

• Supplemental PDB -

  MIPA574.
  

• Supplemental PDB -

  R-enantiomer_MIPA573.
  

• Supplemental PDB -

  R-enantiomer_MIPA574.
  

• Supplemental PDB -

  S-enantiomer_MIPA572.
  

• Supplemental PDB -

  S-enantiomer_MIPA573.
  

• Supplemental PDB -

  R-enantiomer_MIPA572.