Fast Forward

Molecular Pharmacology Fast Forward contains papers in manuscript form that have been accepted and published in Molecular Pharmacology but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

Articles

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Tacrine induces endoplasmic reticulum-stressed apoptosis via disrupting the proper assembly of oligomeric acetylcholinesterase in cultured neuronal cells
Etta Y.L. Liu, Shinghung Mak, Xiangpeng Kong, Yingjie Xia, Kenneth K.L. Kwan, Miranda L. Xu and Karl W.K. Tsim

Molecular Pharmacology September 16, 2021, MOLPHARM-AR-2021-000269; DOI: https://doi.org/10.1124/molpharm.121.000269
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Construction and characterization of CRISPR/Cas9 knockout rat model of carboxylesterase 2a gene
Jie Liu, Xuyang Shang, Shengbo Huang, Yuan Xu, Jian Lu, Yuanjin Zhang, Zongjun Liu and Xin Wang

Molecular Pharmacology September 9, 2021, MOLPHARM-AR-2021-000357; DOI: https://doi.org/10.1124/molpharm.121.000357
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High-content single-cell FRET imaging of cultured striatal neurons reveals novel cross-talk in the regulation of nuclear signalling by PKA and ERK1/2
Jace Jones-Tabah, Ryan D. Martin, Jason C. Tanny, Paul B.S. Clarke and Terence E. Hebert

Molecular Pharmacology September 9, 2021, MOLPHARM-AR-2021-000290; DOI: https://doi.org/10.1124/molpharm.121.000290
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Characterization of VU0468554, a new selective inhibitor of cardiac GIRK channels
Allison Anderson, Baovi N Vo, Ezequiel Marron Fernandez de Velasco, Corey R. Hopkins, C. David Weaver and Kevin Wickman

Molecular Pharmacology September 9, 2021, MOLPHARM-AR-2021-000311; DOI: https://doi.org/10.1124/molpharm.121.000311
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Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites
Siennah R. Miller, Meghan E. McGrath, Kimberley M. Zorn, Sean Ekins, Stephen H. Wright and Nathan J. CHERRINGTON

Molecular Pharmacology September 9, 2021, MOLPHARM-AR-2021-000333; DOI: https://doi.org/10.1124/molpharm.121.000333
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Therapeutic neuroprotection by an engineered neurotrophin designed to broadly activate Trk-receptors and to circumvent p75 receptors
Fouad Brahimi, Alba Galan, Sairey Siegel, Stephanie Szobota, Marinko V. Sarumic, Alan C. Foster and H. Uri Saragovi

Molecular Pharmacology August 31, 2021, MOLPHARM-AR-2021-000301; DOI: https://doi.org/10.1124/molpharm.121.000301
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Metformin prevents hyperglycaemia-associated, oxidative stress-induced vascular endothelial dysfunction: essential role for the orphan nuclear receptor, Nr4a1 (Nur77).
Vivek Krishna Pulakazhi Venu, Mahmoud Saifeddine, Koichiro Mihara, Muniba Faiza, Evgueni Gorobets, Andrew J. Flewelling, Darren Derksen, Simon Hirota, Isra Marei, Dana Al-Majid, Majid Motahhary, Hong Ding, Chris R. Triggle and Morley D. Hollenberg

Molecular Pharmacology August 27, 2021, MOLPHARM-AR-2020-000148; DOI: https://doi.org/10.1124/molpharm.120.000148
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Regulation of adrenergic, serotonin and dopamine receptors to inhibit diabetic retinopathy: monotherapies versus combination therapies
Timothy S Kern, Yunpeng Du, Jie Tang, Chieh Allen Lee, Haitao Liu, Alyssa Dreffs, Henri Leinonen, David A Antonetti and Krzysztof Palczewski

Molecular Pharmacology August 15, 2021, MOLPHARM-AR-2021-000278; DOI: https://doi.org/10.1124/molpharm.121.000278
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Pharmacological characterization of the imipridone anti-cancer drug ONC201 reveals a negative allosteric mechanism of action at the D₂ dopamine receptor
R. Benjamin Free, Caroline A Cuoco, Bing Xie, Yoon Namkung, Varun V. Prabhu, Blair K.A. Willette, Marilyn M. Day, Marta Sanchez-Soto, J. Robert Lane, Stephane A. Laporte, Lei Shi, Joshua E. Allen and David R. Sibley

Molecular Pharmacology August 5, 2021, MOLPHARM-AR-2021-000336; DOI: https://doi.org/10.1124/molpharm.121.000336
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ADP ribosylation factor 6 promotes contraction and proliferation, suppresses apoptosis and is specifically inhibited by NAV2729 in prostate stromal cells
Ruixiao Wang, Stephanie Schneider, Oliver T. Keppler, Bingsheng Li, Beata Rutz, Anna Ciotkowska, Christian G. Stief and Martin Hennenberg

Molecular Pharmacology August 4, 2021, MOLPHARM-AR-2021-000304; DOI: https://doi.org/10.1124/molpharm.121.000304
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CPL207280 - a novel GPR40/FFA1-specific agonist shows a favorable safety profile and exerts anti-diabetic effects in type 2 diabetic animals.
Katarzyna Bazydlo-Guzenda, Pawel Buda, Mikolaj Matloka, Mateusz Mach, Filip Stelmach, Radoslaw Dzida, Damian Smuga, Joanna Hucz-Kalitowska, Malgorzata Teska-Kaminska, Varvara Vialichka, Krzysztof Dubiel, Bozena Kaminska, Maciej Wieczorek and Jerzy Pieczykolan

Molecular Pharmacology August 4, 2021, MOLPHARM-AR-2021-000260; DOI: https://doi.org/10.1124/molpharm.121.000260
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β₂-Adrenoceptor Agonists Promote ERK1/2 Dephosphorylation in Human Airway Epithelial Cells by Canonical, cAMP-driven Signaling Independently of β-Arrestin 2
Omar Hamed, Radhika Joshi, Aubrey N. Michi, Cora Kooi and Mark A. Giembycz

Molecular Pharmacology August 2, 2021, MOLPHARM-AR-2021-000294; DOI: https://doi.org/10.1124/molpharm.121.000294
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Membrane-facilitated receptor access and binding mechanisms of long-acting β2-adrenergic receptor (β2-AR) agonists
Christopher T. Szlenk, Jeevan B. GC and Senthil Natesan

Molecular Pharmacology August 1, 2021, MOLPHARM-AR-2021-000285; DOI: https://doi.org/10.1124/molpharm.121.000285
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Current Understanding of Membrane Transporters as Regulators or Targets for Cisplatin-Induced Hearing Loss
Kyle Z Pasquariello, Jason M. Dey and Jason A. Sprowl

Molecular Pharmacology July 30, 2021, MOLPHARM-AR-2021-000274; DOI: https://doi.org/10.1124/molpharm.121.000274
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Acylation of the incretin peptide exendin-4 directly impacts GLP-1 receptor signalling and trafficking
Maria Lucey, Tanyel Ashik, Amaara Marzook, Yifan Wang, Joelle Goulding, Atsuro Oishi, Johannes Broichhagen, David J Hodson, James Minnion, Yuval Elani, Ralf Jockers, Steven J Briddon, Stephen R Bloom, Alejandra Tomas and Ben Jones

Molecular Pharmacology July 27, 2021, MOLPHARM-AR-2021-000270; DOI: https://doi.org/10.1124/molpharm.121.000270
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Eribulin activates the cGAS-STING pathway via the cytoplasmic accumulation of mtDNA
Charles S. Fermaintt, Leila Takahashi-Ruiz, Huiyun Liang, Susan L. Mooberry and April L. Risinger

Molecular Pharmacology July 26, 2021, MOLPHARM-AR-2021-000297; DOI: https://doi.org/10.1124/molpharm.121.000297

Emerging Concepts

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Membrane-mediated Activity of Local Anesthetics
Stephan Grage, Anke Culetto, Anne Ulrich and Stefan W. Weinschenk

Molecular Pharmacology September 2, 2021, MOLPHARM-EMC-2021-000252; DOI: https://doi.org/10.1124/molpharm.121.000252

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Decoding the cardiac actions of protein kinase D isoforms
Susan F. Steinberg

Molecular Pharmacology September 16, 2021, MOLPHARM-AR-2021-000341; DOI: https://doi.org/10.1124/molpharm.121.000341
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The tails of PKA
Susan S. Taylor, Kristoffer Søberg, Evan Kobori, Jian Wu, Sabine Pautz, Friedrich W. Herberg and Bjørn Steen Skålhegg

Molecular Pharmacology July 30, 2021, MOLPHARM-MR-2021-000315; DOI: https://doi.org/10.1124/molpharm.121.000315
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CCT and CCT-like Modular Protein Interaction Domains in WNK Signaling
Clinton A. Taylor and Melanie H. Cobb

Molecular Pharmacology July 26, 2021, MOLPHARM-MR-2021-000307; DOI: https://doi.org/10.1124/molpharm.121.000307
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mTOR Regulation of AGC Kinases: New Twist to an Old Tail
Timothy R. Baffi and Alexandra C. Newton

Molecular Pharmacology June 21, 2021, MOLPHARM-MR-2021-000310; DOI: https://doi.org/10.1124/molpharm.121.000310

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