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Insights into the Structure-Activity Relationship of Glycosides as Positive Allosteric Modulators Acting on P2X7 Receptors
Waraporn Piyasirananda, Andrew Beekman, A. Ganesan, Stefan Bidula and Leanne Stokes

Molecular Pharmacology February 2021, 99 (2) 163-174; DOI: https://doi.org/10.1124/molpharm.120.000129
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Predicting Drug Interactions with Human Equilibrative Nucleoside Transporters 1 and 2 Using Functional Knockout Cell Lines and Bayesian Modeling
Siennah R. Miller, Xiaohong Zhang, Raymond K. Hau, Joseph L. Jilek, Erin Q. Jennings, James J. Galligan, Daniel H. Foil, Kimberley M. Zorn, Sean Ekins, Stephen H. Wright and Nathan J. Cherrington

Molecular Pharmacology February 2021, 99 (2) 147-162; DOI: https://doi.org/10.1124/molpharm.120.000169
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GABA_A Receptors Expressed in Oligodendrocytes Cultured from the Neonatal Rat Contain α3 and γ1 Subunits and Present Differential Functional and Pharmacological Properties
Rainald Pablo Ordaz, Edith Garay, Agenor Limon, Alberto Pérez-Samartín, María Victoria Sánchez-Gómez, Leticia Robles-Martínez, Abraham Cisneros-Mejorado, Carlos Matute and Rogelio O. Arellano

Molecular Pharmacology February 2021, 99 (2) 133-146; DOI: https://doi.org/10.1124/molpharm.120.000091
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CRISPR/Cas9 Genome Editing of the Human Topoisomerase IIα Intron-19 5′ Splice Site Circumvents Etoposide Resistance in Human Leukemia K562 Cells
Victor A. Hernandez, Jessika Carvajal-Moreno, Jonathan L. Papa, Nicholas Shkolnikov, Junan Li, Hatice Gulcin Ozer, Jack C. Yalowich and Terry S. Elton

Molecular Pharmacology January 14, 2021, MOLPHARM-AR-2020-000173; DOI: https://doi.org/10.1124/molpharm.120.000173
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A potential role for SerpinA3N in acetaminophen-induced hepatotoxicity
Melanie Tran, Jianguo Wu, Li Wang and Dong-Ju Shin

Molecular Pharmacology January 12, 2021, MOLPHARM-AR-2020-000117; DOI: https://doi.org/10.1124/molpharm.120.000117
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Mechanism-based Inactivation of Cytochrome P450 3A4 by Benzbromarone
Lloyd Wei Tat Tang, Ravi Kumar Verma, Hao Fan and Eric Chun Yong Chan

Molecular Pharmacology January 12, 2021, MOLPHARM-AR-2020-000086; DOI: https://doi.org/10.1124/molpharm.120.000086
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Molecular Mechanisms for the Inflammation-Resolving Actions of Lenabasum
Sumner Burstein

Molecular Pharmacology February 2021, 99 (2) 125-132; DOI: https://doi.org/10.1124/molpharm.120.000083
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Macrophage-Inducible C-Type Lectin Signaling Exacerbates Acetaminophen-Induced Liver Injury by Promoting Kupffer Cell Activation in Mice
Jing Zhao, Jong-Won Kim, Zixiong Zhou, Jing Qi, Weishun Tian, Chae Woong Lim, Kang Min Han and Bumseok Kim

Molecular Pharmacology February 2021, 99 (2) 92-103; DOI: https://doi.org/10.1124/molpharm.120.000043
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Identification and Characterization of a Novel Large-Conductance Calcium-Activated Potassium Channel Activator, CTIBD, and Its Relaxation Effect on Urinary Bladder Smooth Muscle
Narasaem Lee, Bong Hee Lim, Kyu-Sung Lee, Jimin Shin, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Sung Won Lee, Tong Mook Kang and Chul-Seung Park

Molecular Pharmacology February 2021, 99 (2) 114-124; DOI: https://doi.org/10.1124/molpharm.120.000106
Open Access
Distinct Regulation of Cardiac Fibroblast Proliferation and Transdifferentiation by Classical and Novel Protein Kinase C Isoforms: Possible Implications for New Antifibrotic Therapies
S. Tuuli Karhu, Heikki Ruskoaho and Virpi Talman

Molecular Pharmacology February 2021, 99 (2) 104-113; DOI: https://doi.org/10.1124/molpharm.120.000094

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