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A Point Mutation at C151 of Keap1 of Mice Abrogates NRF2 Signaling, Cytoprotection In Vitro and Hepatoprotection In Vivo by Bardoxolone Methyl (CDDO-Me)
Tonibelle Gatbonton-Schwager, Yoko Yagishita, Tanvi Joshi, Nobunao Wakabayashi, Harini Srinivasan, Takafumi Suzuki, Masayuki Yamamoto and Thomas W Kensler

Molecular Pharmacology May 15, 2023, MOLPHARM-AR-2023-000671; DOI: https://doi.org/10.1124/molpharm.123.000671
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Rigorous Characterization of Allosteric Modulation of the Human Metabotropic Glutamate Receptor 1 Reveals Probe- and Assay-Dependent Pharmacology
Ashwin Muraleetharan, Yuyang Wang, Matthew C. Rowe, Ashleigh Gould, Karen J. Gregory and Shane D. Hellyer

Molecular Pharmacology June 2023, 103 (6) 325-338; DOI: https://doi.org/10.1124/molpharm.122.000664
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Determinants of Subtype-Selectivity of the Anthelmintic Paraherquamide A on Caenorhabditis elegans Nicotinic Acetylcholine Receptors
Wataru Koizumi, Shuya Otsubo, Shogo Furutani, Kunihiro Niki, Koichi Takayama, Shota Fujimura, Takanobu Maekawa, Ryosuke Koyari, Makoto Ihara, Kenji Kai, Hideo Hayashi, Mohammad Shaokat Ali, Eriko Kage-Nakadai, David B. Sattelle and Kazuhiko Matsuda

Molecular Pharmacology June 2023, 103 (6) 299-310; DOI: https://doi.org/10.1124/molpharm.122.000601
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In Vitro Pharmacological Profile of KW-6356, a Novel Adenosine A_2A Receptor Antagonist/Inverse Agonist
Yutaro Ohno, Michihiko Suzuki, Hidetsugu Asada, Tomoyuki Kanda, Mayumi Saki, Hikaru Miyagi, Mai Yasunaga, Chiyo Suno, So Iwata, Jun-ichi Saito and Shinichi Uchida

Molecular Pharmacology June 2023, 103 (6) 311-324; DOI: https://doi.org/10.1124/molpharm.122.000633
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Human α6β4 Nicotinic Acetylcholine Receptor: Heterologous Expression and Agonist Behavior Provide Insights into the Immediate Binding Site
María Constanza Maldifassi, Hugo Rego Campello, Timothy Gallagher, Henry A. Lester and Dennis A. Dougherty

Molecular Pharmacology June 2023, 103 (6) 339-347; DOI: https://doi.org/10.1124/molpharm.123.000672
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Multi-omics analyses identify PREPL as a key regulator of protein trafficking, a pathway underlying Alzheimer's disease pathogenesis
Mariana Lemos Duarte, Minghui Wang, Ivone Gomes, Chenge Liu, Ali Sharma, Amanda K Fakira, Achla Gupta, Seshat M. Mack, Bin Zhang and Lakshmi A. Devi

Molecular Pharmacology May 5, 2023, MOLPHARM-AR-2022-000641; DOI: https://doi.org/10.1124/molpharm.122.000641
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Differential Activity of Orthosteric Agonists and Allosteric Modulators at Metabotropic Glutamate Receptor 7
Xia Lei, Christopher Hofmann, Alice L Rodriguez and Colleen Niswender

Molecular Pharmacology April 27, 2023, MOLPHARM-AR-2023-000678; DOI: https://doi.org/10.1124/molpharm.123.000678
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BAY58-2667 Activates Different Soluble Guanylyl Cyclase Species by Distinct Mechanisms that Indicate Its Principal Target in Cells is the Heme-Free Soluble Guanylyl Cyclase-Heat Shock Protein 90 Complex
Yue Dai and Dennis J. Stuehr

Molecular Pharmacology May 2023, 103 (5) 286-296; DOI: https://doi.org/10.1124/molpharm.122.000624
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Correction to “The Common LncRNAs of Neuroinflammation-Related Diseases”
Molecular Pharmacology May 2023, 103 (5) 298; DOI: https://doi.org/10.1124/molpharm.122.000530err
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Alkannin Attenuates Amyloid β Aggregation and Alzheimer’s Disease Pathology
Toru Hosoi, Kyosuke Yazawa, Michihiro Imada, Akari Tawara, Chihiro Tohda, Yasuyuki Nomura and Koichiro Ozawa

Molecular Pharmacology May 2023, 103 (5) 266-273; DOI: https://doi.org/10.1124/molpharm.121.000468

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