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Molecular Pharmacology

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Latest Articles

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    Identification of Celecoxib targeted proteins using label-free thermal proteome profiling on rat hippocampus
    Elham Gholizadeh, Reza Karbalaei, Ali Khaleghian, Mona Salimi, Kambiz Gilany, Rabah Soliymani, Ziaurrehman Tanoli, Hassan Rezadoost, Marc Baumann, Mohieddin Jafari and Jing Tang
    Molecular Pharmacology February 25, 2021, MOLPHARM-AR-2020-000210; DOI: https://doi.org/10.1124/molpharm.120.000210
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    CRISPR/Cas9 Genome Editing of the Human Topoisomerase IIα Intron 19 5′ Splice Site Circumvents Etoposide Resistance in Human Leukemia K562 Cells
    Victor A. Hernandez, Jessika Carvajal-Moreno, Jonathan L. Papa, Nicholas Shkolnikov, Junan Li, Hatice Gulcin Ozer, Jack C. Yalowich and Terry S. Elton
    Molecular Pharmacology March 2021, 99 (3) 226-241; DOI: https://doi.org/10.1124/molpharm.120.000173
  • Biased Effect of Cardiotonic Steroids on Na/K-ATPase–Mediated Signal Transduction
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    Biased Effect of Cardiotonic Steroids on Na/K-ATPase–Mediated Signal Transduction
    Yunhui Xu, Pauline Marck, Minqi Huang, Jeffrey X. Xie, Tong Wang, Joseph I. Shapiro, Liquan Cai, Feng Feng and Zijian Xie
    Molecular Pharmacology March 2021, 99 (3) 217-225; DOI: https://doi.org/10.1124/molpharm.120.000101
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    Positive allosteric modulators of metabotropic glutamate receptor 5 as tool compounds to study signaling bias
    Angela Arsova, Thor C. Møller, Shane D. Hellyer, Line Vedel, Simon R. Foster, Jakob L. Hansen, Hans Bräuner-Osborne and Karen J. Gregory
    Molecular Pharmacology February 18, 2021, MOLPHARM-AR-2020-000185; DOI: https://doi.org/10.1124/molpharm.120.000185
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    Transcriptome-Level Interactions between Budesonide and Formoterol Provide Insight into the Mechanism of Action of Inhaled Corticosteroid/Long-Acting β2-Adrenoceptor Agonist Combination Therapy in Asthma
    Mahmoud M. Mostafa, Christopher F. Rider, N. Dulmini Wathugala, Richard Leigh, Mark A. Giembycz and Robert Newton
    Molecular Pharmacology March 2021, 99 (3) 197-216; DOI: https://doi.org/10.1124/molpharm.120.000146
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    Title: Phosphoproteomic Analysis as an Approach for Understanding Molecular Mechanisms of cAMP-dependent Actions
    Joseph A. Beavo, Martin Golkowski, Masami Shimizu-Albergine, Michael-Claude Beltejar, Karin E. Bornfeldt and Shao-En Ong
    Molecular Pharmacology February 11, 2021, MOLPHARM-MR-2020-000197; DOI: https://doi.org/10.1124/molpharm.120.000197
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    Elevated cAMP protects against diclofenac-induced toxicity in primary rat hepatocytes: a protective effect mediated by EPACs
    Fabio Alejandro Aguilar Mora, Nshunge Musheshe, Asmaa Oun, Manon Buist-Homan, Frank Lezoualc'h, Xiaodong Cheng, Martina Schmidt and Han Moshage
    Molecular Pharmacology February 11, 2021, MOLPHARM-AR-2020-000217; DOI: https://doi.org/10.1124/molpharm.120.000217
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    Nelfinavir and Its Active Metabolite M8 Are Partial Agonists and Competitive Antagonists of the Human Pregnane X Receptor
    Oliver Burk, Thales Kronenberger, Oliver Keminer, Serene M. L. Lee, Tobias S. Schiergens, Matthias Schwab and Björn Windshügel
    Molecular Pharmacology March 2021, 99 (3) 184-196; DOI: https://doi.org/10.1124/molpharm.120.000116
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    Short-Term Acyl-CoA:Cholesterol Acyltransferase Inhibition, Combined with Apoprotein A1 Overexpression, Promotes Atherosclerosis Inflammation Resolution in Mice
    Jaume Amengual, Yoscar Ogando, Cyrus Nikain, Alexandra Quezada, Kun Qian, Tomas Vaisar and Edward A. Fisher
    Molecular Pharmacology March 2021, 99 (3) 175-183; DOI: https://doi.org/10.1124/molpharm.120.000108
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    Chronic exposure to SCO-267, an allosteric GPR40 full agonist, is effective in improving glycemic control in rats
    Ryokichi Koyama, Mitsugi Ookawara, Masanori Watanabe and Yusuke Moritoh
    Molecular Pharmacology February 5, 2021, MOLPHARM-AR-2020-000168; DOI: https://doi.org/10.1124/molpharm.120.000168

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