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The Emerging Role of Neuronal Organoid Models in Drug Discovery: Potential Applications and Hurdles to Implementation
Laura A. Struzyna and Marla L. Watt

Molecular Pharmacology April 2021, 99 (4) 256-265; DOI: https://doi.org/10.1124/molpharm.120.000142
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A Potential Role for SerpinA3N in Acetaminophen-Induced Hepatotoxicity
Melanie Tran, Jianguo Wu, Li Wang and Dong-Ju Shin

Molecular Pharmacology April 2021, 99 (4) 277-285; DOI: https://doi.org/10.1124/molpharm.120.000117
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CRISPR/Cas9 Genome Editing of the Human Topoisomerase IIα Intron 19 5′ Splice Site Circumvents Etoposide Resistance in Human Leukemia K562 Cells
Victor A. Hernandez, Jessika Carvajal-Moreno, Jonathan L. Papa, Nicholas Shkolnikov, Junan Li, Hatice Gulcin Ozer, Jack C. Yalowich and Terry S. Elton

Molecular Pharmacology March 2021, 99 (3) 226-241; DOI: https://doi.org/10.1124/molpharm.120.000173
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Biased Effect of Cardiotonic Steroids on Na/K-ATPase–Mediated Signal Transduction
Yunhui Xu, Pauline Marck, Minqi Huang, Jeffrey X. Xie, Tong Wang, Joseph I. Shapiro, Liquan Cai, Feng Feng and Zijian Xie

Molecular Pharmacology March 2021, 99 (3) 217-225; DOI: https://doi.org/10.1124/molpharm.120.000101
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Transcriptome-Level Interactions between Budesonide and Formoterol Provide Insight into the Mechanism of Action of Inhaled Corticosteroid/Long-Acting β₂-Adrenoceptor Agonist Combination Therapy in Asthma
Mahmoud M. Mostafa, Christopher F. Rider, N. Dulmini Wathugala, Richard Leigh, Mark A. Giembycz and Robert Newton

Molecular Pharmacology March 2021, 99 (3) 197-216; DOI: https://doi.org/10.1124/molpharm.120.000146
Open Access
Nelfinavir and Its Active Metabolite M8 Are Partial Agonists and Competitive Antagonists of the Human Pregnane X Receptor
Oliver Burk, Thales Kronenberger, Oliver Keminer, Serene M. L. Lee, Tobias S. Schiergens, Matthias Schwab and Björn Windshügel

Molecular Pharmacology March 2021, 99 (3) 184-196; DOI: https://doi.org/10.1124/molpharm.120.000116
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Short-Term Acyl-CoA:Cholesterol Acyltransferase Inhibition, Combined with Apoprotein A1 Overexpression, Promotes Atherosclerosis Inflammation Resolution in Mice
Jaume Amengual, Yoscar Ogando, Cyrus Nikain, Alexandra Quezada, Kun Qian, Tomas Vaisar and Edward A. Fisher

Molecular Pharmacology March 2021, 99 (3) 175-183; DOI: https://doi.org/10.1124/molpharm.120.000108
Open Access
Insights into the Structure-Activity Relationship of Glycosides as Positive Allosteric Modulators Acting on P2X7 Receptors
Waraporn Piyasirananda, Andrew Beekman, A. Ganesan, Stefan Bidula and Leanne Stokes

Molecular Pharmacology February 2021, 99 (2) 163-174; DOI: https://doi.org/10.1124/molpharm.120.000129
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Predicting Drug Interactions with Human Equilibrative Nucleoside Transporters 1 and 2 Using Functional Knockout Cell Lines and Bayesian Modeling
Siennah R. Miller, Xiaohong Zhang, Raymond K. Hau, Joseph L. Jilek, Erin Q. Jennings, James J. Galligan, Daniel H. Foil, Kimberley M. Zorn, Sean Ekins, Stephen H. Wright and Nathan J. Cherrington

Molecular Pharmacology February 2021, 99 (2) 147-162; DOI: https://doi.org/10.1124/molpharm.120.000169
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GABA_A Receptors Expressed in Oligodendrocytes Cultured from the Neonatal Rat Contain α3 and γ1 Subunits and Present Differential Functional and Pharmacological Properties
Rainald Pablo Ordaz, Edith Garay, Agenor Limon, Alberto Pérez-Samartín, María Victoria Sánchez-Gómez, Leticia Robles-Martínez, Abraham Cisneros-Mejorado, Carlos Matute and Rogelio O. Arellano

Molecular Pharmacology February 2021, 99 (2) 133-146; DOI: https://doi.org/10.1124/molpharm.120.000091

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