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Elevated cAMP Protects against Diclofenac-Induced Toxicity in Primary Rat Hepatocytes: A Protective Effect Mediated by the Exchange Protein Directly Activated by cAMP/cAMP-Regulated Guanine Nucleotide Exchange Factors
Fabio Alejandro Aguilar Mora, Nshunge Musheshe, Asmaa Oun, Manon Buist-Homan, Frank Lezoualc’h, Xiaodong Cheng, Martina Schmidt and Han Moshage

Molecular Pharmacology April 2021, 99 (4) 294-307; DOI: https://doi.org/10.1124/molpharm.120.000217
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Mechanism-Based Inactivation of Cytochrome P450 3A4 by Benzbromarone
Lloyd Wei Tat Tang, Ravi Kumar Verma, Hao Fan and Eric Chun Yong Chan

Molecular Pharmacology April 2021, 99 (4) 266-276; DOI: https://doi.org/10.1124/molpharm.120.000086
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The Emerging Role of Neuronal Organoid Models in Drug Discovery: Potential Applications and Hurdles to Implementation
Laura A. Struzyna and Marla L. Watt

Molecular Pharmacology April 2021, 99 (4) 256-265; DOI: https://doi.org/10.1124/molpharm.120.000142
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A Potential Role for SerpinA3N in Acetaminophen-Induced Hepatotoxicity
Melanie Tran, Jianguo Wu, Li Wang and Dong-Ju Shin

Molecular Pharmacology April 2021, 99 (4) 277-285; DOI: https://doi.org/10.1124/molpharm.120.000117
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Arrestin-Dependent and -Independent Internalization of G Protein–Coupled Receptors: Methods, Mechanisms, and Implications on Cell Signaling
Ee Von Moo, Jeffrey R. van Senten, Hans Bräuner-Osborne and Thor C. Møller

Molecular Pharmacology April 2021, 99 (4) 242-255; DOI: https://doi.org/10.1124/molpharm.120.000192
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Chronic Exposure to SCO-267, an Allosteric GPR40 Full Agonist, Is Effective in Improving Glycemic Control in Rats
Ryokichi Koyama, Mitsugi Ookawara, Masanori Watanabe and Yusuke Moritoh

Molecular Pharmacology April 2021, 99 (4) 286-293; DOI: https://doi.org/10.1124/molpharm.120.000168
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CRISPR/Cas9 Genome Editing of the Human Topoisomerase IIα Intron 19 5′ Splice Site Circumvents Etoposide Resistance in Human Leukemia K562 Cells
Victor A. Hernandez, Jessika Carvajal-Moreno, Jonathan L. Papa, Nicholas Shkolnikov, Junan Li, Hatice Gulcin Ozer, Jack C. Yalowich and Terry S. Elton

Molecular Pharmacology March 2021, 99 (3) 226-241; DOI: https://doi.org/10.1124/molpharm.120.000173
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Biased Effect of Cardiotonic Steroids on Na/K-ATPase–Mediated Signal Transduction
Yunhui Xu, Pauline Marck, Minqi Huang, Jeffrey X. Xie, Tong Wang, Joseph I. Shapiro, Liquan Cai, Feng Feng and Zijian Xie

Molecular Pharmacology March 2021, 99 (3) 217-225; DOI: https://doi.org/10.1124/molpharm.120.000101
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Transcriptome-Level Interactions between Budesonide and Formoterol Provide Insight into the Mechanism of Action of Inhaled Corticosteroid/Long-Acting β₂-Adrenoceptor Agonist Combination Therapy in Asthma
Mahmoud M. Mostafa, Christopher F. Rider, N. Dulmini Wathugala, Richard Leigh, Mark A. Giembycz and Robert Newton

Molecular Pharmacology March 2021, 99 (3) 197-216; DOI: https://doi.org/10.1124/molpharm.120.000146
Open Access
Nelfinavir and Its Active Metabolite M8 Are Partial Agonists and Competitive Antagonists of the Human Pregnane X Receptor
Oliver Burk, Thales Kronenberger, Oliver Keminer, Serene M. L. Lee, Tobias S. Schiergens, Matthias Schwab and Björn Windshügel

Molecular Pharmacology March 2021, 99 (3) 184-196; DOI: https://doi.org/10.1124/molpharm.120.000116

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