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The Isoleucine at Position 118 in Transmembrane 2 Is Responsible for the Selectivity of Xamoterol, Nebivolol, and ICI89406 for the Human β1-Adrenoceptor
Victor Jun Yu Lim, Richard G. W. Proudman, Stefania Monteleone, Peter Kolb and Jillian G. Baker

Molecular Pharmacology February 2023, 103 (2) 89-99; DOI: https://doi.org/10.1124/molpharm.122.000583
Open Access
Differences in Sustained Cellular Effects of MET inhibitors Are Driven by Prolonged Target Engagement and Lysosomal Retention
Nina Berges, Jan Henrik Klug, Anna Eicher, Jennifer Loehr, Daniel Schwarz, Joerg Bomke, Birgitta Leuthner, Dominique Perrin and Oliver Schadt

Molecular Pharmacology February 2023, 103 (2) 77-88; DOI: https://doi.org/10.1124/molpharm.122.000590
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Insights Into the Differential Desensitization of α4β2 Nicotinic Acetylcholine Receptor Isoforms Obtained With Positive Allosteric Modulation of Mutant Receptors
Roger L. Papke and Clare Stokes

Molecular Pharmacology February 2023, 103 (2) 63-76; DOI: https://doi.org/10.1124/molpharm.122.000591
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Protein Kinases and Cross-talk between Post-translational Modifications in the Regulation of Drug Transporters
Xuyang Wang and Mei Hong

Molecular Pharmacology January 2023, 103 (1) 9-20; DOI: https://doi.org/10.1124/molpharm.122.000604
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A Regional and Projection-Specific Role of RGSz1 in the Ventrolateral Periaqueductal Grey in the Modulation of Morphine Reward
Farhana Sakloth, Omar B. Sanchez-Reyes, Anne Ruiz, Andrew Nicolais, Randal A. Serafini, Kerri D. Pryce, Feodora Bertherat, Angélica Torres-Berrío, Ivone Gomes, Lakshmi A. Devi, Daniel Wacker and Venetia Zachariou

Molecular Pharmacology January 2023, 103 (1) 1-8; DOI: https://doi.org/10.1124/molpharm.122.000528
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Targeting Circuit Abnormalities in Neurodegenerative Disease
Sharan Ram Srinivasan

Molecular Pharmacology January 2023, 103 (1) 38-44; DOI: https://doi.org/10.1124/molpharm.122.000563
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Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis
Carolina Montañez-Miranda, Riley E. Perszyk, Nicholas H. Harbin, Jennifer Okalova, Suneela Ramineni, Stephen F. Traynelis and John R. Hepler

Molecular Pharmacology January 2023, 103 (1) 21-37; DOI: https://doi.org/10.1124/molpharm.122.000614
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Transcriptional Regulation, Signaling Pathways, and Subcellular Localization of Corticotropin-Releasing Factor Receptors in the Central Nervous System
Paula Amado, Juan Zegers, Hector E. Yarur and Katia Gysling

Molecular Pharmacology December 2022, 102 (6) 280-287; DOI: https://doi.org/10.1124/molpharm.121.000476
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A Sentimental Segue
Molecular Pharmacology December 2022, 102 (6) 288-289; DOI: https://doi.org/10.1124/molpharm.122.000632
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Announcement
Molecular Pharmacology December 2022, 102 (6) 291; DOI: https://doi.org/10.1124/molpharm.122.000635

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