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Molecular Pharmacology

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Latest Articles

  • Open Access
    Naturally Occurring Mutations to Muscle-Type Creatine Kinase Impact Its Canonical and Pharmacological Activities in a Substrate-Dependent Manner In Vitro
    Eric P. Mosher, Colten D. Eberhard and Namandjé N. Bumpus
    Molecular Pharmacology December 2021, 100 (6) 588-596; DOI: https://doi.org/10.1124/molpharm.121.000348
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    Potential Use of Senolytics for Pharmacological Targeting of Precancerous Lesions
    Tareq Saleh and Valerie J. Carpenter
    Molecular Pharmacology December 2021, 100 (6) 580-587; DOI: https://doi.org/10.1124/molpharm.121.000361
  • Tacrine Induces Endoplasmic Reticulum–Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells
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    Tacrine Induces Endoplasmic Reticulum–Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells
    Etta Y.L. Liu, Shinghung Mak, Xiangpeng Kong, Yingjie Xia, Kenneth K.L. Kwan, Miranda L. Xu and Karl W.K. Tsim
    Molecular Pharmacology November 2021, 100 (5) 456-469; DOI: https://doi.org/10.1124/molpharm.121.000269
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    Therapeutic Neuroprotection by an Engineered Neurotrophin that Selectively Activates Tropomyosin Receptor Kinase (Trk) Family Neurotrophin Receptors but Not the p75 Neurotrophin Receptor
    Fouad Brahimi, Alba Galan, Sairey Siegel, Stephanie Szobota, Marinko V. Sarunic, Alan C. Foster and H. Uri Saragovi
    Molecular Pharmacology November 2021, 100 (5) 491-501; DOI: https://doi.org/10.1124/molpharm.121.000301
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    Construction and Characterization of CRISPR/Cas9 Knockout Rat Model of Carboxylesterase 2a Gene
    Jie Liu, Xuyang Shang, Shengbo Huang, Yuan Xu, Jian Lu, Yuanjin Zhang, Zongjun Liu and Xin Wang
    Molecular Pharmacology November 2021, 100 (5) 480-490; DOI: https://doi.org/10.1124/molpharm.121.000357
  • Open Access
    Unique Positive Cooperativity Between the β-Arrestin–Biased β-Blocker Carvedilol and a Small Molecule Positive Allosteric Modulator of the β2-Adrenergic Receptor
    Biswaranjan Pani, Seungkirl Ahn, Paula K. Rambarat, Shashank Vege, Alem W. Kahsai, Andrew Liu, Bruno N. Valan, Dean P. Staus, Tommaso Costa and Robert J. Lefkowitz
    Molecular Pharmacology November 2021, 100 (5) 513-525; DOI: https://doi.org/10.1124/molpharm.121.000363
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    Membrane-Mediated Activity of Local Anesthetics
    Stephan L. Grage, Anke Culetto, Anne S. Ulrich and Stefan Weinschenk
    Molecular Pharmacology November 2021, 100 (5) 502-512; DOI: https://doi.org/10.1124/molpharm.121.000252
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    Regulation of Adrenergic, Serotonin, and Dopamine Receptors to Inhibit Diabetic Retinopathy: Monotherapies versus Combination Therapies
    Timothy S. Kern, Yunpeng Du, Jie Tang, Chieh Allen Lee, Haitao Liu, Alyssa Dreffs, Henri Leinonen, David A. Antonetti and Krzysztof Palczewski
    Molecular Pharmacology November 2021, 100 (5) 470-479; DOI: https://doi.org/10.1124/molpharm.121.000278
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    Metformin Prevents Hyperglycemia-Associated, Oxidative Stress-Induced Vascular Endothelial Dysfunction: Essential Role for the Orphan Nuclear Receptor Human Nuclear Receptor 4A1 (Nur77)
    Vivek Krishna Pulakazhi Venu, Mahmoud Saifeddine, Koichiro Mihara, Muniba Faiza, Evgueni Gorobets, Andrew J. Flewelling, Darren J. Derksen, Simon A. Hirota, Isra Marei, Dana Al-Majid, Majid Motahhary, Hong Ding, Chris R. Triggle and Morley D. Hollenberg
    Molecular Pharmacology November 2021, 100 (5) 428-455; DOI: https://doi.org/10.1124/molpharm.120.000148
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    Membrane-Facilitated Receptor Access and Binding Mechanisms of Long-Acting β2-Adrenergic Receptor Agonists
    Christopher T. Szlenk, Jeevan B. GC and Senthil Natesan
    Molecular Pharmacology October 2021, 100 (4) 406-427; DOI: https://doi.org/10.1124/molpharm.121.000285

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