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Molecular Pharmacology

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Latest Articles

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    β2-Adrenoceptor Agonists Promote Extracellular Signal-Regulated Kinase 1/2 Dephosphorylation in Human Airway Epithelial Cells by Canonical, cAMP-Driven Signaling Independently of β-Arrestin 2
    Omar Hamed, Radhika Joshi, Aubrey N. Michi, Cora Kooi and Mark A. Giembycz
    Molecular Pharmacology October 2021, 100 (4) 388-405; DOI: https://doi.org/10.1124/molpharm.121.000294
  • Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA
    Open Access
    Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA
    Charles S. Fermaintt, Leila Takahashi-Ruiz, Huiyun Liang, Susan L. Mooberry and April L. Risinger
    Molecular Pharmacology October 2021, 100 (4) 309-318; DOI: https://doi.org/10.1124/molpharm.121.000297
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    Pharmacological Characterization of the Imipridone Anticancer Drug ONC201 Reveals a Negative Allosteric Mechanism of Action at the D2 Dopamine Receptor
    R. Benjamin Free, Caroline A. Cuoco, Bing Xie, Yoon Namkung, Varun V. Prabhu, Blair K.A. Willette, Marilyn M. Day, Marta Sanchez-Soto, J. Robert Lane, Stéphane A. Laporte, Lei Shi, Joshua E. Allen and David R. Sibley
    Molecular Pharmacology October 2021, 100 (4) 372-387; DOI: https://doi.org/10.1124/molpharm.121.000336
  • Open Access
    CPL207280, a Novel G Protein–Coupled Receptor 40/Free Fatty Acid Receptor 1–Specific Agonist, Shows a Favorable Safety Profile and Exerts Antidiabetic Effects in Type 2 Diabetic Animals
    Katarzyna Bazydlo-Guzenda, Pawel Buda, Mikolaj Matloka, Mateusz Mach, Filip Stelmach, Radoslaw Dzida, Damian Smuga, Joanna Hucz-Kalitowska, Malgorzata Teska-Kaminska, Varvara Vialichka, Krzysztof Dubiel, Bozena Kaminska, Maciej Wieczorek and Jerzy Pieczykolan
    Molecular Pharmacology October 2021, 100 (4) 335-347; DOI: https://doi.org/10.1124/molpharm.121.000260
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    ADP Ribosylation Factor 6 Promotes Contraction and Proliferation, Suppresses Apoptosis and Is Specifically Inhibited by NAV2729 in Prostate Stromal Cells
    Ruixiao Wang, Stephanie Schneider, Oliver T. Keppler, Bingsheng Li, Beata Rutz, Anna Ciotkowska, Christian G. Stief and Martin Hennenberg
    Molecular Pharmacology October 2021, 100 (4) 356-371; DOI: https://doi.org/10.1124/molpharm.121.000304
  • Open Access
    Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking
    Maria Lucey, Tanyel Ashik, Amaara Marzook, Yifan Wang, Joëlle Goulding, Atsuro Oishi, Johannes Broichhagen, David J. Hodson, James Minnion, Yuval Elani, Ralf Jockers, Stephen J. Briddon, Stephen R. Bloom, Alejandra Tomas and Ben Jones
    Molecular Pharmacology October 2021, 100 (4) 319-334; DOI: https://doi.org/10.1124/molpharm.121.000270
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    Current Understanding of Membrane Transporters as Regulators or Targets for Cisplatin-Induced Hearing Loss
    Kyle Z. Pasquariello, Jason M. Dey and Jason A. Sprowl
    Molecular Pharmacology October 2021, 100 (4) 348-355; DOI: https://doi.org/10.1124/molpharm.121.000274
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    Correction to “High-Throughput Screening of Transient Receptor Potential Channel 1 Ligands in the Light of the Bioluminescence Resonance Energy Transfer Technique”
    Molecular Pharmacology September 2021, 100 (3) 308; DOI: https://doi.org/10.1124/molpharm.121.000271err
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    Dynamic Expression of Transient Receptor Potential Vanilloid-3 and Integrated Signaling with Growth Factor Pathways during Lung Epithelial Wound Repair following Wood Smoke Particle and Other Forms of Lung Cell Injury
    Katherine L. Burrell, Nam D. Nguyen, Cassandra E. Deering-Rice, Tosifa A. Memon, Marysol Almestica-Roberts, Emmanuel Rapp, Samantha N. Serna, John G. Lamb and Christopher A. Reilly
    Molecular Pharmacology September 2021, 100 (3) 295-307; DOI: https://doi.org/10.1124/molpharm.121.000280
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    The Benzene Hematotoxic and Reactive Metabolite 1,4-Benzoquinone Impairs the Activity of the Histone Methyltransferase SET Domain Containing 2 (SETD2) and Causes Aberrant Histone H3 Lysine 36 Trimethylation (H3K36me3)
    Jérémy Berthelet, Christina Michail, Linh-Chi Bui, Louise Le Coadou, Valentina Sirri, Li Wang, Nicolas Dulphy, Jean-Marie Dupret, Christine Chomienne, Fabien Guidez and Fernando Rodrigues-Lima
    Molecular Pharmacology September 2021, 100 (3) 283-294; DOI: https://doi.org/10.1124/molpharm.121.000303

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