Abstract
The rates of recovery of response of rabbit aortic strips, blocked with N,N-dimethyl-2-bromo-2-phenylethylamine, to noradrenaline, adrenaline, N-ethyl- and N-isopropyl-noradrenaline have been determined. The close similarities of these recovery rates suggests that "spare" receptors are of little significance in this system.
The use of 3H-labeled N,N-dimethyl-2-bromo-2-phenylethylamine enabled an estimate of the concentration of α-receptors, 1.15 x 1012 receptors per milligram of tissue dry weight, to be made and also provided good evidence for the view that tissue response is proportional to the concentration of agonist-receptor complex.
ACKNOWLEDGMENTS The authors wish to acknowledge the assistance of Miss Marlene Calderone. This investigation was supported by a grant from the National Institute of Health, U. S. Public Health Service (GM 11603).
- Copyright ©, 1967, by Academic Press Inc.
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