Abstract
The following evidence suggests that the reduction of p-nitrobenzoate to p-aminobenzoate by liver microsomes is mediated by cytochrome P-450: (a) carbon monoxide blocks nitroreduction, and the degree of inhibition is proportional to the amount of cytochrome P-450 bound as the carbon monoxide complex; (b) the rate of nitroreduction is proportional to the amount of cytochrome P-450 in liver microsomes from animals previously treated with either phenobarbital or carbon tetrachloride.
- Copyright ©, 1968, by Academic Press Inc.
MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years.Non-open access articles that fall outside this five year window are available only to institutional subscribers and current ASPET members, or through the article purchase feature at the bottom of the page.
|
Log in using your username and password
Purchase access
You may purchase access to this article. This will require you to create an account if you don't already have one.