Abstract
Reserpine produces a neurally mediated increase in tyrosine hydroxylase activity in the adrenal medullae and sympathetic ganglia of the rat. This increase in enzyme activity can be prevented by the administration of actinomycin D or cycloheximide. These results suggest that the synthesis of tyrosine hydroxylase is regulated either by changes in the release or turnover of catecholamines, or by the direct effect of a neurotransmitter. Reserpine increases the incorporation of 3H-leucine into hepatic and adrenal protein, and this incorporation is inhibited by a dose of cycloheximide that prevents the reserpine-initiated increase in tyrosine hydroxylase activity.
- Copyright ©, 1969, by Academic Press Inc.
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