Abstract
The responsiveness to 5-fluoro-2'-deoxyuridine of different transplantable mouse leukemias in vivo was inversely correlated with tumor cell levels of thymidine kinase (EC 2.7.1.21). This enzyme transforms the drug to the pharmacologically active nucleotide 5-fluoro-2'-deoxyuridylic acid. However, it also provides an alternative pathway for circumventing time drug-induced blockade of thymidylate biosynthesis.
ACKNOWLEDGMENTS Technical assistance was provided by Regina Bruns (at the University of Rochester) and Albert Ross (at Arthur D. Little Corporation).
- Copyright ©, 1970, by Academic Press Inc.
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