%PDF-1.4
%
180 0 obj
<>
endobj
182 0 obj
<>stream
2021-01-07T10:16:41-05:00
2024-03-29T05:21:39-07:00
2024-03-29T05:21:39-07:00
itext-paulo-155 (itextpdf.sf.net-lowagie.com)
application/pdf
Mechanism-based Inactivation of Cytochrome P450 3A4 by Benzbromarone
uuid:0b5bd8ad-1dd2-11b2-0a00-aa09277d8900
uuid:0b5bd8af-1dd2-11b2-0a00-d30000000000
endstream
endobj
171 0 obj
<>
endobj
1 0 obj
<>
endobj
2 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 0/Tabs/S/Type/Page>>
endobj
3 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 2/Tabs/S/Type/Page>>
endobj
4 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 4/Tabs/S/Type/Page>>
endobj
5 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 5/Tabs/S/Type/Page>>
endobj
6 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 6/Tabs/S/Type/Page>>
endobj
7 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 7/Tabs/S/Type/Page>>
endobj
8 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 8/Tabs/S/Type/Page>>
endobj
9 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 9/Tabs/S/Type/Page>>
endobj
10 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 10/Tabs/S/Type/Page>>
endobj
11 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 11/Tabs/S/Type/Page>>
endobj
12 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 12/Tabs/S/Type/Page>>
endobj
13 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 13/Tabs/S/Type/Page>>
endobj
14 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 14/Tabs/S/Type/Page>>
endobj
15 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 15/Tabs/S/Type/Page>>
endobj
16 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 16/Tabs/S/Type/Page>>
endobj
17 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 17/Tabs/S/Type/Page>>
endobj
18 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 18/Tabs/S/Type/Page>>
endobj
19 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 19/Tabs/S/Type/Page>>
endobj
20 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 20/Tabs/S/Type/Page>>
endobj
21 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 21/Tabs/S/Type/Page>>
endobj
22 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 22/Tabs/S/Type/Page>>
endobj
23 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 23/Tabs/S/Type/Page>>
endobj
24 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 24/Tabs/S/Type/Page>>
endobj
25 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 25/Tabs/S/Type/Page>>
endobj
26 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 26/Tabs/S/Type/Page>>
endobj
27 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 27/Tabs/S/Type/Page>>
endobj
28 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 28/Tabs/S/Type/Page>>
endobj
29 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 29/Tabs/S/Type/Page>>
endobj
30 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 30/Tabs/S/Type/Page>>
endobj
31 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/ProcSet[/PDF/Text]>>/StructParents 31/Tabs/S/Type/Page>>
endobj
32 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 32/Tabs/S/Type/Page>>
endobj
33 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 33/Tabs/S/Type/Page>>
endobj
34 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 34/Tabs/S/Type/Page>>
endobj
35 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 35/Tabs/S/Type/Page>>
endobj
36 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 36/Tabs/S/Type/Page>>
endobj
37 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 37/Tabs/S/Type/Page>>
endobj
38 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 38/Tabs/S/Type/Page>>
endobj
39 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 39/Tabs/S/Type/Page>>
endobj
40 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 40/Tabs/S/Type/Page>>
endobj
41 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 41/Tabs/S/Type/Page>>
endobj
42 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 42/Tabs/S/Type/Page>>
endobj
43 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 43/Tabs/S/Type/Page>>
endobj
44 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 44/Tabs/S/Type/Page>>
endobj
45 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 1/Tabs/S/Type/Page>>
endobj
46 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 45/Tabs/S/Type/Page>>
endobj
47 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 46/Tabs/S/Type/Page>>
endobj
48 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 47/Tabs/S/Type/Page>>
endobj
49 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 48/Tabs/S/Type/Page>>
endobj
50 0 obj
<>/MediaBox[0 0 595.32 841.92]/Parent 1 0 R/Resources<>/Font<>/ProcSet[/PDF/Text]>>/StructParents 49/Tabs/S/Type/Page>>
endobj
51 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
52 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
53 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
54 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
55 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
56 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
57 0 obj
<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Type/Page>>
endobj
333 0 obj
[335 0 R]
endobj
334 0 obj
<>stream
HLP]k0}[LR6T@X#K"%!=XHT+JbB'IFw)$[6}m}C {65f`JUMDd2*iٝ6u8TG
خ@Ck8LP֝mB_\Pe[́=*J!TUo\~jl/X~ڇ
D=횺HqdR=@ %Ab_'PRٴ1q(*lW&/G
=Fa&OnKo26u' k@
endstream
endobj
169 0 obj
<>stream
x{U3 "ix"O=VV=75DQ< Ax6_,33ͳYj)= YN30ڟ\}3ڳ}XZ^Z볮k}1c1c1c1c1c1c1c1c1c1c1c1c1c1c1c1c1c1c1c1c1c1c1c1c1c1c1c1c1c1uy0aBCCCzI&[jUke1c1c1c)odܸqݗ/_~GftMc1c1c1S
KKf#aɒ%6{խ:c1c1c1-ai|3g%\ޝ:u:ꨣ.]ک3c1c1c>b444,]tyuuur%KԴu˗u];wNvvw^{Sg1c1c1ƴ=Z]ZZx5YhQ3S[[;nܸ#F_{ntA
+{f's'M5?MtիWO81SO=/?eԩ)O?+{]uUGq;\UUE nV{o [r3# -K=fyiiΜ9GuT3rOu|pP~H]]رcLgySg1c1c1ƴaڨlٲOfΜy4=Ê@SNmR&lh.\(>xΜ9:c1c1c1m%TF֭[߾}/o#^zueBI*hѢQF:cǎ7;x`ӧO?~mv!SSwߍg~zmͤs]v~ک3c1c1cf̘2
GݩS2ZLwe2K/7nѢEV\#WUU_~ԩz*zk7)6o1Ifm6dȐիWv1c1c1Ƙ6O)iO>XO̚5ݛ*-qOmvvu)Sy'Y+-Pw}w[Kq>G]&
?я|.~bC@
oּv{k:c1c1c1@)ii=}ݛ$-544L:uM6߮]vۭ_~ݻMg[ڷoOcƌ|_\L)s̹xΝ;uf1c1c1|dhCҢE~x`CCCMn椥m٦u]+lzkܻ[nZ1` 7?O[+Uc1c1cG"-?swo#^G_mIK;w8p`7oGB;0rI ӧOfm2Wb-~_7R20KUUUt[+Uc1c1cG"-xo6+VhS/Ydw\mIKm]%K3f+tkmR
/SN9W[wy晼#tM$c1c1c1J[jjj9gϞxj6hРڐTUU/}^z rz뭛%-[ӟ4sM6٤ye̜9sĈ,ַpVI1c1c1Qo7\KKK,ƌӌ͋#mHZرc>}*ex|3glRE]]?r*W#O<[lIώ;x-|z1c1c1Ƙ6뮻^x⭶*/<ի|ڐԵk/rO?=_[n
'?矟`=-[֤Ywy|tvpec1c1cYi>h߾}6_l}gֆ-آrxEKy;̝;IPO?[nI6ls嗷dJ1c1c1Ƙ mEZ9sf>]v>}z3;dֶnΛ7W^EKyϘ1I̙3/Χd4iRKc1c1c&ɓ'/Zy?~j-#-ؠҜ9s:蠢~~M֤YG瞙dtuС-c1c1c1C_x|"uOoCC[oZHK/fm2ٳ-vm7eʔ&eȺ@ d?b0c1c1c>V iaʔ)Dvmɒ%o}} 2Wki>رc:ZZzoszʮI.P%=C{mdc1c1c1+ڄa齖^}fwժUӟ2Wki?E s:tA/W&O\SSӤi6uuu)s[ni4c1c1c1Cڊt!/ok}~_TfǨ
*--X_~+TWWޕ'~cw6lX>3Q[;uc1c1cG"--^xٹs;Sɫ-ZZZjرcYE5*=zbĉ;sP4c1c1c1L[,Y}.sdǎfwݻw\ғO>YMWXq9zCKK$?qn+RySjseTjjjNwqGˤc1c1cxVN8!sd{U__ߤ^zܸqG./-^t>CߗnhiiժUO>dv2j|SLnMniӦ5jw:th>'뭷j4c1c1c1OڊT[[{
7ٵkMeˊ
e%N92wo
o&l>,h1[ou";vӧի+Xh)/K/j?Lt2pI1c1c1HK>lCqIرcHKwޙ7ds9X/.- -͝;gϞ[ӟ~*·_̥>O=#MT}2 ѣ- 0c1c1c>δiIo}>'_}
E<\FZZbEO]v{UzӆI&u֭}[@Z"o馼0s7qi#FgŮ:gΜʯlf͚uK_RS1c1c1TڐrK.$gٲek
2MPFZ֗]vY.]]}Νwz
Z@Z~{]v߽{'Nlhh"dOg.f&ټ{w&UUUַVX2i0c1c1c>!iaڴi]vͧCJ9ս(|jժx JUU՞{9{RH{WFWDKIKK,+K{7`W\ԧ>viʔ)MJO Ǎ߲[n#Glc1c1c1sڐa!0݈#%KpXmmʕ+lٲ9sr-{W}e%"EU>K܈*PWW-Z_/ߖ(v- +_OUUU_җ<^xg}Gݡ)Oyifܹs^nw{/=/~#ZFZڱcrRpqǑ~x%,X0q.lw/z&y̘1cd&Lh4c1c1c1gڜ{v(.UBuu'?̗奥իW?PlMb7eAꪎ;I${[9"mݞ{fyL<Χd'Z,c1c1cǖ6'-}Xpg{G:t>p:uwŊ~zp|Э['cƌ|ߒ,ZhȑCt}̘1-c1c1c1cԩSj_}}{ܺiI\?Ν;`ԩ[o}彖t\"mUV+"s@% cŊ{Q>8^$̟??/npb1c1c1Ƙ'3fr-XzfȐ![ovcǎ"˖-;>mv6ҥKΝ;u_>[l_wuӦM)7xcFWrǺ7{W];vؾ}*y |ni=ŋljկ҇'?N;-XԽ;R&?<0w.'ʸbPd>^zqu{3x/|]7k|z1c1c1ӦY|/0v;?=c_5kVȕ+W^tEkz巫饗?_n6w}9.?덍ٳgu]soK۬ n喻!rO>k1c1c1?#-me>͚5_6~{nƌ+Wltc1c1c1ƴ&K.{3V[m*qތ1c1c1c̆`q1͜9K.TUUկ~uCc1c1c1ƴ</?W^iu㎌Rǎ/
rc1c1c1,Y䳟lFԩӘ1ct9s|_\k'N@)7c1c1c1-{ꕑn^dҥ_|q"ڵ>獖1c1c1c>2֎396dѣG/_,Y_sE2Oa1c1c1cZ7xcM7ͫK:t8'ObŊիWYVZlٛo9xvM4c1c1c1Ƭwjjj?vUuvgw}>ᄏhѢ~矿{եKguon'3c1c1c19.EEf&{kg1c1c1c"VЭ[RKӱc}w٭Lc1c1c1fCz{lwdM+m槜r|Oc1c1c1c6,7jԨݻwԩrM7tvZ!1c1c1cL2wkf=ҥKΝ;vءCvڷo7|ϯ[m~kpc1c1c1:\