Supplemental Data
Files in this Data Supplement:
- Supplemental Data -
Experimental procedure
Supplementary figure 1 - Competition binding assays
Supplementary figure 2 - BETP and Compound 2 selectively potentiate the affinity of oxyntomodulin
Supplementary figure 3 - Compound 2 displays positive allosteric effects on GLP-1Rmediated cAMP accumulation in an agonist-dependent manner
Supplementary figure 4 - Compound 2 does not alter GLP-1R-mediated iCa2+ mobilisation by peptide ligands
Supplementary figure 5 - Compound 2 displays negative allosteric effects on GLP-1Rmediated pERK1/2 by peptide ligands
Supplementary figure 6 - BMS21 does not modulate peptide-mediated GLP-1R signalling
Supplementary figure 7 - Boc5 displays behaviour consistent with competitive interaction with peptides in GLP-1R-mediated signalling
Supplementary figure 8 - TT15 displays behaviour consistent with competitive interaction with peptides in GLP-1R-mediated signalling
Supplementary figure 9 - BMS21, Boc5 and TT15 display behaviour consistent with competitive interaction when interacted together in GLP-1R-mediated cAMP signalling