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Molecular Pharmacology

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Research ArticleArticle

Investigation of the Fate of Type I Angiotensin Receptor after Biased Activation

Gyongyi Szakadati, Andras D Toth, Ilona Olah, Laszlo S Erdelyi, Tamas Balla, Peter Varnai, Laszlo Hunyady and Andras Balla
Molecular Pharmacology March 24, 2015, mol.114.097030; DOI: https://doi.org/10.1124/mol.114.097030
Gyongyi Szakadati
1 Department of Physiology, Semmelweis University;
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Andras D Toth
1 Department of Physiology, Semmelweis University;
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Ilona Olah
1 Department of Physiology, Semmelweis University;
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Laszlo S Erdelyi
2 Department of Physiology, Semmelweis University; MTA-SE Laboratory of Molecular Physiology, HAS;
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Tamas Balla
3 Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH
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Peter Varnai
2 Department of Physiology, Semmelweis University; MTA-SE Laboratory of Molecular Physiology, HAS;
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Laszlo Hunyady
2 Department of Physiology, Semmelweis University; MTA-SE Laboratory of Molecular Physiology, HAS;
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Andras Balla
2 Department of Physiology, Semmelweis University; MTA-SE Laboratory of Molecular Physiology, HAS;
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Data Supplement

Files in this Data Supplement:

  • Supplemental Figures -

    Supplemental Figure 1 - Effects of AT1-R agonist stimulation on PtdIns(4,5)P2 breakdown in HEK293 cells

    Supplemental Figure 2 - Functional analysis of the AT1-R-Rluc and AT1-R-DRY/AAY-Rluc

    Supplemental Figure 3 - BRET assay between AT1-R and Rab5 upon either AngII or SII-AngII stimulation in HEK293 cells

    Supplemental Figure 4 - Effect of intracellular Ca2+ chelation on AT1-R internalization upon AngII stimulation in HEK293 cells

    Supplemental Figure 5 - Dose-response curves of AT1-R induced PtdIns(4,5)P2 hydrolysis (A), beta-arrestin2 binding (B), and Rab5 recruitment (C) in HEK293 cells

    Supplemental Figure 6 - BRET assay between wild type or mutant AT1-Rs and beta-arrestin2 or Rab5 upon either AngII or SII-AngII stimulation in HEK293 cells

    Supplemental Figure 7 - Plasma membrane PtdIns(4,5)P2 depletion effects AT1-R internalization

    Supplemental Figure 8 - Effects of DN-GRK overexpression on plasma membrane PtdIns(4,5)P2 hydrolysis and beta-arrestin2 binding of AT1-R

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