A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures.

Data Supplement

Files in this Data Supplement:

• Supplemental Data -

  Supplementary Figure 1 - Hydrogen bonds for the polar network residues of the GLP-1R apo inactive receptor during the 240 ns molecular dynamics simulation

• Supplemental Table -

  ECL1 distance constraints and other constraints used in Modeller

• GLP1R_full-length_GLP1 bound_G protein peptide bound.pdb -

  Full-length, peptide bound model of the human GLP-1 receptor

• GLP1R apo.pdb -

  Inactive transmembrane domain model of the human GLP-1 receptor

• Supplemental Movie -

  Close up of the polar network residues of GLP-1R during the molecular dynamics simulations