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Molecular Pharmacology

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Research ArticleArticle

WNT stimulation dissociates a Frizzled 4 inactive state complex with Gα12/13

Elisa Arthofer, Belma Hot, Julian Petersen, Katerina Strakova, Stefan Jager, Manuel Grundmann, Evi Kostenis, Silvio J Gutkind and Gunnar Schulte
Molecular Pharmacology July 25, 2016, mol.116.104919; DOI: https://doi.org/10.1124/mol.116.104919
Elisa Arthofer
1 Karolinska Institutet, Dept Physiology & Physiology/ National Institutres of Health NIH, NIDCH;
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Belma Hot
2 Karolinska Institutet, Dept Physiology & Physiology;
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Julian Petersen
2 Karolinska Institutet, Dept Physiology & Physiology;
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Katerina Strakova
2 Karolinska Institutet, Dept Physiology & Physiology;
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Stefan Jager
2 Karolinska Institutet, Dept Physiology & Physiology;
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Manuel Grundmann
3 University of Bonn;
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Evi Kostenis
3 University of Bonn;
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Silvio J Gutkind
4 University of California San Diego, Dept. Pharmacology, Moores Cancer Center;
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Gunnar Schulte
5 Karolinska Institutet, Dept Physiology & Pharmacology
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Data Supplement

Files in this Data Supplement:

  • Supplemental Figures -

    Supplemental Figure 1 - Functional validation of C terminally-tagged FZD4-GFP, FZD4- mCherry and FZD4-Cerulean in comparison to untagged FZD4 by DVL recruitment

    Supplemental Figure 2 - Functional validation of N terminally-tagged G12-mCherry employing p115-RHOGEF recruitment

    Supplemental Figure 3 - Functional validation of N terminally-tagged G13-mCherry employing p115-RHOGEF recruitment

    Supplemental Figure 4 - Quantification of LPA1 receptor-mediated p115-RHOGEF-GFP recruitment

    Supplemental Figure 5 - Expression levels of FZD4-GFP and forskolin-induced DMR responses in wt and Gα12/13-knock out HEK293 cells

    Supplemental Figure 6 - Expression levels of DVL1, 2, 3 in HEK293 cells treated with ctrl and panDVL siRNA

  View article

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