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Molecular Pharmacology

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Research ArticleArticle

State-dependent allosteric inhibition of the human SLC13A5 citrate transporter by hydroxysuccinic acids, PF-06649298 and PF-06761281

Marie-Laure Rives, Morena Shaw, Bin Zhu, Simon A Hinke and Alan Wickenden
Molecular Pharmacology October 17, 2016, mol.116.106575; DOI: https://doi.org/10.1124/mol.116.106575
Marie-Laure Rives
1 Janssen;
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Morena Shaw
1 Janssen;
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Bin Zhu
1 Janssen;
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Simon A Hinke
1 Janssen;
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Alan Wickenden
2 Janssen R&D, L.L.C
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Data Supplement

Files in this Data Supplement:

  • Supplemental Figures -

    Supplemental Figure 1 - Functional validation of HEK293TRex-TO/hSLC13A5 cells

    Supplemental Figure 2 - Succinate is a competitive inhibitor of citrate uptake at hSLC13A5

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