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Molecular Pharmacology

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Research ArticleArticle

Myeloperoxidase enhances etoposide and mitoxantrone mediated DNA damage: a target for myeloprotection in cancer chemotherapy

Mandeep Atwal, Emma L Lishman, Caroline A Austin and Ian G Cowell
Molecular Pharmacology November 10, 2016, mol.116.106054; DOI: https://doi.org/10.1124/mol.116.106054
Mandeep Atwal
Newcastle University
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Emma L Lishman
Newcastle University
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Caroline A Austin
Newcastle University
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Ian G Cowell
Newcastle University
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Data Supplement

Data Supplement

Files in this Data Supplement:

  • Data Supplement -

    Supplemental Figure 1 - MPO is expressed in CD34+ bone marrow cells

    Supplemental Figure 2 - (A) Enzymatic oxidation of etoposide

    Supplemental Figure 3 - (A& B) Example of a single replicate experiment of the TARDIS TOP2A (A) and TOP2B (B) covalent complex quantification shown in Fig 1 C and D

    Supplemental Figure 4 - (A) Inhibition of MPO activity in NB4 cells by PF-1355 and MPOi-II

    Supplemental References

    Supplemental Table 1 - MPO activity affects etoposide and mitoxantrone-induced TOP2 CC and γH2AX levels and associated statistics

    Supplemental Table 2 - Effect of MPO inhibition and GSH depletion on etoposide and mitoxantrone-induced TOP2 CC and γH2AX levels and associated statistics

    Supplemental Table 3 - Comparison of the effects of succinylacetone and direct MPO inhibitors on etoposide and mitoxantrone-induced TOP2-DNA covalent complexes and H2AX phosphorylation

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