Data Supplement
Data Supplement
Files in this Data Supplement:
- Data Supplement -
Supplemental Figure 1 - MPO is expressed in CD34+ bone marrow cells
Supplemental Figure 2 - (A) Enzymatic oxidation of etoposide
Supplemental Figure 3 - (A& B) Example of a single replicate experiment of the TARDIS TOP2A (A) and TOP2B (B) covalent complex quantification shown in Fig 1 C and D
Supplemental Figure 4 - (A) Inhibition of MPO activity in NB4 cells by PF-1355 and MPOi-II
Supplemental References
Supplemental Table 1 - MPO activity affects etoposide and mitoxantrone-induced TOP2 CC and γH2AX levels and associated statistics
Supplemental Table 2 - Effect of MPO inhibition and GSH depletion on etoposide and mitoxantrone-induced TOP2 CC and γH2AX levels and associated statistics
Supplemental Table 3 - Comparison of the effects of succinylacetone and direct MPO inhibitors on etoposide and mitoxantrone-induced TOP2-DNA covalent complexes and H2AX phosphorylation