Data Supplement
- Supplemental Data -
Supplemental Table 1 - Functional affinity (pKB) and cooperativity (Logαβ) parameters for AC265347 determined in Ca2+i mobilization assays using an interaction paradigm described in Materials and Methods
Supplemental Figure 1- NPSR568 modulation of Ca2+o-mediated Ca2+i mobilization viaactivation of the WT CaSR and mutants thereof
Supplemental Figure 2 - NPSR568 modulation of AC265347-mediated Ca2+i mobilization via activation of the WT CaSR and Y8256.42A mutant
Supplemental Figure 3- Predicted binding poses for NPSR568 and cinacalcet in a CaSR homology model
Supplemental Figure 4 - F6843.36A and F6883.40A reduce Ca2+o efficacy but not affinity at the CaSR
Supplemental Figure 5 - 7TM and ECL mutations alter Ca2+o potency