Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity

Data Supplement

• Supplemental Data -

  Supplemental Figure 1 - Molecular model of the interaction of tenofovir with serine at the position 203 of hOAT1
  
  

  Supplemental Figure 2 - Kinetics of PAH uptake by hOAT1 and cyOAT1
  
  

  Supplemental Figure 3 - Correlation of serum uric acid concentration with tenofovir transport efficiency for OAT1
  
  

  Supplemental Figure 4 - Regional plot of the SLC22A6 locus
  
  

  Supplemental Table 1 - Primers
  
  

  Supplemental Table 2 - Amino acid sequence identity between hOAT1 and orthologs from cynomolgus monkey, mouse, rat and dog
  
  

  Supplemental Table 3 - Quantification of membrane-bound OAT1 protein in stable cell lines and kidney cortex from human, cynomolgus monkey, mouse, rat and dog
  
  

  Supplemental Table 4 - List of the amino acid at position 203 in hOAT1 and the equivalent position in OAT1 orthologs from primates and more distant species
  
  

  Supplemental Table 5 - Kinetic parameters of PAH uptake by hOAT1 and cyOAT1
  
  

  Supplemental Table 7 - Summary of statistical analysis results for Table 1, Table 2, Table 3 and Table 6
  
  

• Supplemental Table 6 -

  Allele frequency of each populations in 1000 genomes