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Molecular Pharmacology

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Research ArticleArticle

Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity

Ling Zou, Adrian Stecula, Anshul Gupta, Bhagwat Prasad, Huan-Chieh Chien, Sook Wah Yee, Li Wang, Jashvant D Unadkat, Simone H Stahl, Katherine S Fenner and Kathleen M Giacomini
Molecular Pharmacology May 2, 2018, mol.117.111153; DOI: https://doi.org/10.1124/mol.117.111153
Ling Zou
1 Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco;
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Adrian Stecula
1 Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco;
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Anshul Gupta
2 Pharmacokinetics and Drug Metabolism, Amgen Inc.;
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Bhagwat Prasad
3 Department of Pharmaceutics, School of Pharmacy, University of Washington;
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Huan-Chieh Chien
1 Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco;
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Sook Wah Yee
1 Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco;
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Li Wang
3 Department of Pharmaceutics, School of Pharmacy, University of Washington;
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Jashvant D Unadkat
3 Department of Pharmaceutics, School of Pharmacy, University of Washington;
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Simone H Stahl
4 ADME Transporters, Safety and ADME Translational Sciences, Drug Safety and Metabolism IMED, AstraZen
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Katherine S Fenner
4 ADME Transporters, Safety and ADME Translational Sciences, Drug Safety and Metabolism IMED, AstraZen
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Kathleen M Giacomini
1 Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco;
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Data Supplement

  • Supplemental Data -

    Supplemental Figure 1 - Molecular model of the interaction of tenofovir with serine at the position 203 of hOAT1

    Supplemental Figure 2 - Kinetics of PAH uptake by hOAT1 and cyOAT1

    Supplemental Figure 3 - Correlation of serum uric acid concentration with tenofovir transport efficiency for OAT1

    Supplemental Figure 4 - Regional plot of the SLC22A6 locus

    Supplemental Table 1 - Primers

    Supplemental Table 2 - Amino acid sequence identity between hOAT1 and orthologs from cynomolgus monkey, mouse, rat and dog

    Supplemental Table 3 - Quantification of membrane-bound OAT1 protein in stable cell lines and kidney cortex from human, cynomolgus monkey, mouse, rat and dog

    Supplemental Table 4 - List of the amino acid at position 203 in hOAT1 and the equivalent position in OAT1 orthologs from primates and more distant species

    Supplemental Table 5 - Kinetic parameters of PAH uptake by hOAT1 and cyOAT1

    Supplemental Table 7 - Summary of statistical analysis results for Table 1, Table 2, Table 3 and Table 6

  • Supplemental Table 6 -

    Allele frequency of each populations in 1000 genomes

  View article

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