The effects of farnesoid X receptor activation on arachidonic acid metabolism, NF-kB signaling and hepatic inflammation

Data Supplement

• Supplemental Figures -

  Supplemental Figure 1 - NASH assessment in mice fed a HFD

  Supplemental Figure 2 - Arachidonic acid metabolism in mice fed a HFD

  Supplemental Figure 3 - Effect of OCA on HFD-induced NASH

  Supplemental Figure 4 - Effect of OCA on the expression of FXR target genes in Huh7 cells

  Supplemental Figure 5 - Impact of FXR activation on FFA-induced monocyte migration and EET metabolism-related gene expression levels in primary cultured hepatocytes from mouse (A and B) and human (C and D)

  Supplemental Figure 6 - Effect of the co-incubation with OCA and the FXR antagonist z-Guggulsterone (Gu) on FXR activation and FFA-induced monocyte migration

  Supplemental Figure 7 - Effect of OCA, Gemfibrozil (GM) or Rifampicin (Rifa) on THP-1 cell migration induced by serum or exogenous LTB4