Hyperforin induced activation of the Pregnane X Receptor is influenced by the Organic Anion Transporting Polypeptide 2B1 (OATP2B1)

Data Supplement

• Supplemental Figures -

  Supplemental Figure 1 - Counterflow experiments performed in MDCKII cells
  

  Supplemental Figure 2 - Competitive counterflow experiment with hyperforin (A) or hypericin (B)
  

  Supplemental Figure 3 - Chromatograms of a mixture of the references hypericin (TOCRIS) and pseudohypericin (Sigma-Aldrich), and of the 11 in Switzerland marketed St. John’s wort formulations
  

  Supplemental Figure 4 - Chromatograms of the reference hyperforin (Sigma-Aldrich) and of the 11 in Switzerland marketed St. John’s wort formulations.