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Molecular Pharmacology

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Research ArticleArticle

The basis for strain-dependent rat aldehyde dehydrogenase 1A7 (ALDH1A7) gene expression

Katerina Touloupi, Jenni Kublbeck, Angeliki Magklara, Ferdinand Molnar, Mika Reinisalo, Maria Konstandi, Paavo Honkakoski and Periklis Pappas
Molecular Pharmacology October 1, 2019, mol.119.117424; DOI: https://doi.org/10.1124/mol.119.117424
Katerina Touloupi
1 University of Ioannina;
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Jenni Kublbeck
2 University of Eastern Finland;
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  • ORCID record for Jenni Kublbeck
Angeliki Magklara
1 University of Ioannina;
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Ferdinand Molnar
3 Nazarbayev University
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Mika Reinisalo
2 University of Eastern Finland;
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Maria Konstandi
1 University of Ioannina;
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Paavo Honkakoski
2 University of Eastern Finland;
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Periklis Pappas
1 University of Ioannina;
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Data Supplement

  • Supplemental Data -

    Supplementary Table 1 - Primers for ALDH1A7 cloning.

    Supplementary Table 2 - Primers for ChIP assay.

    Supplementary Table 3 - Predicted transcription factor sites in the RR and rr ALDH1A7 upstream sequences.

    Supplementary Table 4 -  Predicted nuclear receptor binding elements in the RR and rr ALDH1A7 upstream sequences.

    Supplementary Table 5 - Group mean Ct values of -actin, ALDH and CYP mRNAs in the multiple dose study.

    Supplementary Figure 1 - Alignment of the ALDH1A7 promoters from the RR and rr strains.

    Supplementary Figure 2 -  Cytosolic and total ALDH1 protein levels in control, PB- and PCN-treated RR and rr rat livers.

    Supplementary Figure 3 - Total CAR and PXR protein levels in control, PB- and PCN-treated RR and rr rat livers.

    Supplementary Figure 4 - Time course of PB induction in RR and rr rats.

    Supplementary Figure 5 - Time course of PCN induction in RR and rr rats.

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