Insights into the structure-activity relationship of glycosides as positive allosteric modulators acting on P2X7 receptors

Data Supplement

• Supplemental Figures -

  Supplementary Figure 1: Effect of disaccharides stevenleaf and esculentoside A on P2X7.

  Supplementary Figure 2: P2X7 expression in THP-1 monocytes.

• Supplemental Data -

  Supplemental material: PDB file showing 20(S)-Rg3 docked to a homology model of human P2X7 in the predicted open-state. ATP is also shown within the structure. The model shows the central (most-populated) pose generated using Glide software (Schrodinger suite).