Data Supplement
- Supplemental Data -
Supplemental Materials and Methods
Supplemental Table S1 - Hepatocyte donor data.
Supplemental Table S2 - Overview of binding site characteristics and docking scores.
Supplemental Table S3 - Number of docking poses per cluster and their ranking according to the docking score within the set of 100 docking conformations.
Supplemental Table S4 - Rifampin EC50 with increasing doses of nelfinavir and M8.
Supplemental Fig. S1 - Cell toxicity of nelfinavir and M8. HepG2 and H-P cells were treated with increasing concentrations of nelfinavir or M8 metabolite for 24 h. Means ± SD (N=2) are shown.
Supplemental Fig. S2 - Concentration response analyses of the effects of nelfinavir and/or M8 on nuclear receptors beside PXR.
Supplemental Fig. S3 - Effect of nelfinavir on the GAL4-PXR-LBD fusion protein.
Supplemental Fig. S4 - Effect of nelfinavir on PXR activation by the high affinity agonist T0901317.