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OtherArticle

Eribulin activates the cGAS-STING pathway via the cytoplasmic accumulation of mtDNA

Charles S. Fermaintt, Leila Takahashi-Ruiz, Huiyun Liang, Susan L. Mooberry and April L. Risinger
Molecular Pharmacology July 26, 2021, MOLPHARM-AR-2021-000297; DOI: https://doi.org/10.1124/molpharm.121.000297
Charles S. Fermaintt
1Pharmacology, University of Texas Health Science Center at San Antonio, United States
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  • ORCID record for Charles S. Fermaintt
Leila Takahashi-Ruiz
1Pharmacology, University of Texas Health Science Center at San Antonio, United States
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Huiyun Liang
2Pharmacology, UT Health San Antonio, United States
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Susan L. Mooberry
3Pharmacology, Univ. TX Health Sci Center at San Antonio, United States
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  • ORCID record for Susan L. Mooberry
April L. Risinger
1Pharmacology, University of Texas Health Science Center at San Antonio, United States
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  • For correspondence: risingera@uthscsa.edu

Data Supplement

  • Supplemental Data -

    Figure S1. The effects of eribulin and paclitaxel on cytokine expression.

    Figure S2. Eribulin-mediated expression of interferon stimulated genes is dependent on canonical IFN-mediated JAK signaling.

    Figure S3. Pharmacological inhibitors do not increase apoptosis in BMDMs.

    Figure S4. Inhibition of STING suppresses eribulin-mediated interferon β expression.

    Figure S5. Eribulin-mediated expression of interferon stimulated genes in CAL-51 cells is dependent on the DNA sensor cGAS.

    Figure S6. DNA sensing by the cGAS-STING pathway is retained in HCC1937 Rho0 cells.

    Table S1. DNA oligonucleotides used in this study.

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