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Molecular Pharmacology

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OtherArticle

Influence of the TARP γ8-selective negative allosteric modulator JNJ-55511118 on AMPA receptor gating and channel conductance

Ian Coombs, Craig A Sexton, Stuart G. Cull-Candy and Mark Farrant
Molecular Pharmacology March 3, 2022, MOLPHARM-AR-2021-000473; DOI: https://doi.org/10.1124/molpharm.121.000473
Ian Coombs
1University College London, United Kingdom
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  • ORCID record for Ian Coombs
Craig A Sexton
2Neuroscience, Physiology and Pharmacology, University College London, United Kingdom
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Stuart G. Cull-Candy
3Neuroscience, Physiology & Pharmacology, UCL, United Kingdom
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Mark Farrant
2Neuroscience, Physiology and Pharmacology, University College London, United Kingdom
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  • For correspondence: m.farrant@ucl.ac.uk

Data Supplement

  • Supplemental Figure 1 -

    Fig S1. JNJ-118 effects on kinetics and steady-state current of GluA2(Q)/γ8.

  • Supplemental Figure 2 -

    Fig S2. JNJ-118 effects on deactivation and rectification of GluA2(Q)/γ2 and GluA2(Q)/γ2.DM.

  • Supplemental Table 1 -

    Table S1. Omnibus tests for actions of JNJ-118 on GluA2 co-expressed with wild- type or mutated forms of γ8 and γ2.

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