TY - JOUR T1 - Inhibition of Ribonucleic Acid-Directed Deoxyribonucleic Acid Polymerase of Murine Leukemia Virus by Polyribonucleotides and Their 2'-<em>O</em>-Methylated Derivatives JF - Molecular Pharmacology JO - Mol Pharmacol SP - 421 LP - 426 VL - 11 IS - 4 AU - S. K. ARYA AU - W. A. CARTER AU - J. L. ALDERFER AU - P.O.P. TS’O Y1 - 1975/07/01 UR - http://molpharm.aspetjournals.org/content/11/4/421.abstract N2 - Poly(inosinic acid) [poly(I)], poly(2'-O-methylinosinic acid) [poly(Im)], poly(uridylic acid) [pol(U)], and poly(2'-O-methyluridylic acid) [poly(Um)] inhibit the RNA-directed DNA polymerase activity of Moloney murine leukemia virus. Poly(cytidylic acid) [pol(U)], and poly(2'-O-methyluridylic acid) [poly(Um)] inhibit the RNA-inhibition. The apparent inhibition kinetics for poly(I) and poly(Im) inhibition of the poly(A):oligo(dT)-directed reaction and that for poly(U) and poly(Um) inhibition of the poly(C):oligo(dG)-directed reaction are not consistent with a simple competitive inhibition with respect to the template. The following order of the potency of inhibition is observed: poly(I) &gt; poly(Im) &gt; poly(U) &gt; poly(Um) &gt; &gt; poly(C) or poly(Cm). ER -