RT Journal Article
SR Electronic
T1 Inhibition of Ribonucleic Acid-Directed Deoxyribonucleic Acid Polymerase of Murine Leukemia Virus by Polyribonucleotides and Their 2'-<em>O</em>-Methylated Derivatives
JF Molecular Pharmacology
JO Mol Pharmacol
FD American Society for Pharmacology and Experimental Therapeutics
SP 421
OP 426
VO 11
IS 4
A1 S. K. ARYA
A1 W. A. CARTER
A1 J. L. ALDERFER
A1 P.O.P. TS’O
YR 1975
UL http://molpharm.aspetjournals.org/content/11/4/421.abstract
AB Poly(inosinic acid) [poly(I)], poly(2'-O-methylinosinic acid) [poly(Im)], poly(uridylic acid) [pol(U)], and poly(2'-O-methyluridylic acid) [poly(Um)] inhibit the RNA-directed DNA polymerase activity of Moloney murine leukemia virus. Poly(cytidylic acid) [pol(U)], and poly(2'-O-methyluridylic acid) [poly(Um)] inhibit the RNA-inhibition. The apparent inhibition kinetics for poly(I) and poly(Im) inhibition of the poly(A):oligo(dT)-directed reaction and that for poly(U) and poly(Um) inhibition of the poly(C):oligo(dG)-directed reaction are not consistent with a simple competitive inhibition with respect to the template. The following order of the potency of inhibition is observed: poly(I) &gt; poly(Im) &gt; poly(U) &gt; poly(Um) &gt; &gt; poly(C) or poly(Cm).