TY - JOUR T1 - Interactions of the Antibiotic Distamycin A with Homopolymeric Single-Stranded Polydeoxyribonucleotides and with ΦX 174 Deoxyribonucleic Acid JF - Molecular Pharmacology JO - Mol Pharmacol SP - 185 LP - 190 VL - 12 IS - 1 AU - ANNE K. KREY AU - JOHN G. OLENICK AU - FRED E. HAHN Y1 - 1976/01/01 UR - http://molpharm.aspetjournals.org/content/12/1/185.abstract N2 - The absorption spectrum of distamycin A was changed by poly dA, poly dT, poly dG, and poly dC and also by ΦX 174 DNA. Poly dA and, to a lesser extent, poly dG induced a Cotton effect in the optical rotatory dispersion spectrum of distamycin A. The complex of distamycin A and ΦX 174 DNA showed a reverisble cooperative transition upon heating and cooling. Distamycin A inhibited the template activities of poly dA and poly dT in an RNA polymerase reaction in vitro. ER -