PT  - JOURNAL ARTICLE
AU  - MINOU BINA-STEIN
AU  - THOMAS R. TRITTON
TI  - Aurintricarboxylic Acid Is a Nonspecific Enzyme Inhibitor
DP  - 1976 Jan 01
TA  - Molecular Pharmacology
PG  - 191--193
VI  - 12
IP  - 1
4099  - http://molpharm.aspetjournals.org/content/12/1/191.short
4100  - http://molpharm.aspetjournals.org/content/12/1/191.full
SO  - Mol Pharmacol1976 Jan 01; 12
AB  - Aurintricarboxylic acid (ATA) has been previously categorized as a drug which inhibits enzymes of polynucleotide metabolism. In this paper we present evidence that ATA does not show specificity toward this class of enzymes only. Rather, the drug will bind to and inhibit most enzymes regardless of their specific catalytic function. ACKNOWLEDGMENTS We thank Dr. R. E. Handschumacher for purified E. coli asparaginase, Dr. L. Lachman for teaching us the asparaginase assay method, and Dr. F. Kalousek for a gift of E. coli seryl-tRNA synthetase. We are also grateful to Dr. Alan Cooper for stimulating conversations, and to Dr. Julian Sturtevant and Dr. Donald Crothers for providing laboratory space.